Immunogenic polypeptide

Zarling, D.A., Miskimen, J.A., Fan, D.P., Fujimoto, E.K., and Smith, P.K. (1982) Association of Sendai virion envelope and a mouse surface membrane polypeptide on newly infected cells Lack of association with H-2K/D or alteration of viral immunogenicity. /. Immunol. 128, 251-257. 

The exact mechanism of the immunogenicity of species-specific rDNA proteins is unknown, but is believed to be attributable to (1) the addition of extra amino acid residues during synthesis, which the host reads as foreign (2) denaturing of the native molecules or (3) contamination by E. coli polypeptides or lipopolysacchar-ides. 

Carrier A protein, polypeptide, or inert matrix that is coupled to the hapten to form an immunogen ... 

Two types of expression systems based on plant RNA viruses have been developed for production of immunogenic peptides and proteins in plants epitope presentation systems (short antigenic peptides fused to the CP that are displayed on the surface of assembled viral particles) and polypeptide expression systems (these systems express the whole unfused recombinant protein that accumulates within the plant). 

Lyampert, I.M., E.N. Semenova, V. Sanina, N.G. Puchkova, and A.V. Nekrasov, Immunogenicity of a polypeptide fragment of the streptococcal group A M protein conjugated with an acrylic acid N-vinylpyrroli-done copolymer. Biomed Sci, 1991. 2(4) 410-14. 

Dalton, J.P. and Strand, M. (1 987) Schistosoma mansoni polypeptides immunogenic in mice vaccinated with radiation-attenuated cercariae. The Journal of Immunology 1 39, 2474-2481. 

In this example the DNA vaccine (pTHr-HIVA) is based on a novel direct gene transfer vector pTH [77], and the second component, MVA-HIVA, is based on a modified vaccinia virus Ankara. Both of these components contain most of the HIV-1 clade A gag protein coupled to conserved HIV-1 clade A CTL epitopes arranged in a polypeptide string that served as the immunogen [77]. 

Baker, R. S., Schmidtke, J. R., Ross, J. W., and Smith, W. C. (1981). Preliminary studies on the immunogenicity and amount of Escherichia coli polypeptides in biosynthetic human insulin produced by recombinant DNA technology. Lancet 2(8256), pp. 1139-1142. 

Many proteins, polypeptides, oligonucleotides, and other large molecules are immunogenic in the animal models used in pharmacology and toxicology evalu-... 

Polypeptides and proteins closely related to human polypeptides and proteins, but containing known differences in amino acid sequences and/or post- translational modification(s) that may affect biological activity or immunogenicity or both. 

Synthesis and in vitro T cell immunogenicity of conjugates with dual specificities attachment of epitope peptides of 16 kDa and 38 kDa proteins from M. tuberculosis to branched polypeptide. Bioconjugate Chemistry 9, 539-547. 

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