Immune response nephropathies

Pestka, J. J. Deoxynivalenol-induced IgA production and IgA nephropathy-aberrant mucosal immune response with systemic repercussions. Toxicol. Lett. 140-141, 287, 2003. 

An experimental model of metal-induced autoimmunity and nephropathy has been developed in the BN rat, which is genetically predisposed to develop Th2-type of immune response. In the BN rat, the injections of... 

Ueda S, Wakashin Y, Yoshida H, Mori T, Mori Y, Azemoto R, Ogawa M, Kato I, Wakashin M. Gold nephropathy - effect of gold on immune response to renal tubular basement membrane (TBM) antigen in mice. In Nephrotoxicity./nv/fro to in vivo, animals to man. Bach BH, Lock EA, editors. Plenum, New York 1989 p. 139-145. 

Cyclosporine Nephropathy, reversible immune response suppression (essential aid to organ transplantation) Rat, monkey Yes... 

The last three years have expanded insight as to how lymphocytes respond to antigens or xenobiotics, and also the knowledge of the pathophysiology of renal diseases. This provides new clues on the mechanisms by which chemically induced immune responses trigger kidney lesions. First, we will discuss the general mechanisms that could be responsible for drug-induce immune nephropathies. The role of Thl and Th2 CD4+ T-cell subsets in the development of nephropathies will be also debated. Then, we will describe the types of immune nephropathy than can be induced by xenobiotics in patients. Finally, we will focus on experimental models of chemical-induced systemic... 

A. Antiglomerular basement membrane antibodies Some xenobiotics may induce an immune-type glomerulonephritis associated with the occurrence of antibodies against some constituents of the glomerular basement membrane. These antibodies may be directly responsible for the nephropathy or they may be produced as a consequence of non- specific alterations of the normal glomerular basement membrane lattice. 

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