Immune recognition

Interfaces play a predominant role in metabolic processes [78], as well as in immune recognition (e.g. T lymphocytes recognizing antigens on the surface of antigen presenting cells, section c2.14.6.2. Historically, the bulk of experimental... 

Colman, P.M. Structure of antibody-antigen complexes implications for immune recognition. Adv. Immunol. 43 99-132, 1988. 

Investigation of immune recognition segments in presynapsis and postsynapsis neurotoxins (macrocyclic peptides) 98KPS22. 

Janeway CA Jr, Medzhitov R Innate immune recognition. Armu Rev Immunol 2002 20 197-216. Kapsenberg ML Dendritic-cell control of pathogen-driven T-cell polarization. Nat Rev Immunol 2003 3 984-993. 

The beta 2 family has receptors on leukocytes (also called LeuCAM) and mediates inflammatory and immune recognition functions. 

Amino acid Specificity of immune recognition Structural... 

Nilsson B, Korsgren O, Jd L et al (2010) Can cells and biomaterials in therapeutic medicine be shielded from innate immune recognition Trends Immunol 31 32-38... 

Klinman DM, Verthelyi D, Takeshita F, Ishii KJ (1999) Immune recognition of foreign DNA A cure for bioterrorism Immunity 11 123-129. 

CoscoY, L., D. J. Sanchez, and D. Ganem, a novel class of herpesvirus-encoded membrane-bound E3 ubiquitin ligases regulates endocytosis of proteins involved in immune recognition. / Cell Biol, 2001, 155(7), 1265-73. 

Tumor cells in the first metastasis escaped immune recognition due to selective loss of HLA haplotype, but maintain the expression of HLA-A2 antigen. In contrast, in the second metastasis immune escape from immune dominant antigen-specific T cell responses were mediated by HLA class I downregulation which results in the impaired presentation of this epitope, whereas another tumor antigen-specific epitope was presented. This resulted in the shift of the dominant T cell response to a subdominant targeted response. 

The major histocompatibility complex (MHC) is part of the system that codes for molecules important in immune recognition, including graft rejection. MHC class I and II molecules present antigen fragments to T-lymphocytes. For example, class I molecules bind viral proteins and present them to the CD8+ T cells. Exogenous antigens such as proteins taken into the cell by endocytosis are processed within the cell and presented to CD4+ cells. 

Niman, H L., Houghten, R A., Walker, L E., Reisfeld, R A., Wilson, I. A, Hogle, J. M., and Lemer, R, A. (1983) Generation of protein-reactive antibodies by short peptides is an event of high frequency implications for the structural basis of immune recognition Proc Natl Acad Sci USA 80,4949-4953... 

Additional Cell Adhesion Proteins Are Required to Mediate the Immune Response Immune Recognition Molecules Are Evolutionarily Related... 

CD4 55 T cells, NKT cells MHC class Il-restricted immune recognition... 

Yatsuda, A.P., Krijgsveld, J., Cornelissen, A., Heck, A.J.R. and deVries, E. (2003) Comprehensive analysis of the secreted proteins of the parasite ffaemonchus contortus reveals extensive sequence variation and differential immune recognition. Journal of Biological Chemistry 278, 16941-16951. 

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