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Membrane immobilized artificial

Faller, B., Grimm, H. P., Loeuillet-Ritzier, F., Arnold, S., Briand, X. High-throughput lipophilidty measurement with immobilized artificial membranes. J. Med. Chem. 2005, 48, 2571-2576. [Pg.48]

Reichel, A., Begley, D. J. Potential of immobilized artificial membranes for predicting drug penetration across the blood-brain barrier. Pharm. Res. 1998, 35,1270-1274. [Pg.49]

A., Barbato, E., Testa, B. Immobilized artificial membrane (lAM)-HPLC in drug research. /. Med. Chem. 2003, 46, 655-665. [Pg.351]

Pidgeon, C., Venkataram, U. V. Immobilized artificial membrane chromatography supports composed of membrane lipids. Anal. Eiochem. 1989,... [Pg.351]

Vrakas, D., Giaginis, C., Tsantili-Kakoulidou, A. Different retention behavior of structurally diverse basic and neutral drugs in immobilized artificial membrane and reversed-phase high performance liquid chromatography ... [Pg.351]

M., La Rotonda, M. L, Testa, B. Structural properties governing retention mechanisms on immobilized artificial membrane (lAM) HPLC columns. Helv. Chim. Acta 2002, 85, 519-532. [Pg.433]

Hollosy, F., Valko, K., Hersey, A., Nunhuck, S., Keri, G., Bevan, C. Estimation of volume of distribution in humans from high throughput HPLC-based measurements of human serum albumin binding and immobilized artificial membrane partitioning. J. Med. Chem. 2006, 49, 6958-6971. [Pg.434]

A very promising method, immobilized artificial membrane (IAM) chromatography, was developed by Pidgeon and co-workers [299-304,307], where silica resin was modified by covalent attachment of phospholipid-like groups to the surface. The retention parameters mimic the partitioning of drugs into phospholipid bilayers. The topic has been widely reviewed [47,298,307,309-311]. [Pg.54]

In the bulk of this chapter we will focus on the rapidly emerging new in vitro technology based on the use of immobilized artificial membranes, constructed of phospholipid bilayers supported on lipophilic filters. One objective is to complete the coverage of the components of the transport model explored in Chapter 2, by considering the method for determining the top curve (horizontal fine) in the plots... [Pg.117]

Figure 7.15 Kinetics of transport across a filter-immobilized artificial membrane (a) desipramine and (b) dihydromethysticin concentrations in acceptor well. [Reprinted from Avdeef, A., in van de Waterbeemd, H. Lennemas, H. Artursson, R (Eds.). Drug Bioavailability. Estimation of Solubility, Permeability, Absorption and Bioavailability. Wiley-VCH Weinheim, 2003 (in press), with permission from Wiley-VCH Verlag GmbH.]... Figure 7.15 Kinetics of transport across a filter-immobilized artificial membrane (a) desipramine and (b) dihydromethysticin concentrations in acceptor well. [Reprinted from Avdeef, A., in van de Waterbeemd, H. Lennemas, H. Artursson, R (Eds.). Drug Bioavailability. Estimation of Solubility, Permeability, Absorption and Bioavailability. Wiley-VCH Weinheim, 2003 (in press), with permission from Wiley-VCH Verlag GmbH.]...
Pidgeon, C. Ong, S. Choi, H. Liu, H., Preparation of mixed ligand immobilized artificial membranes for predicting drug binding to membranes, Anal. Chem. 66, 2701-2709 (1994). [Pg.267]

Ong, S. Liu, H. Qiu, X. Bhat, G. Pidgeon, C., Membrane partition coefficients chromatographically measured using immobilized artificial membrane surfaces, Anal. Chem. 67, 755-762 (1995). [Pg.267]

Barbato, F. La Rotonda, M. I. Quaglia, E, Interactions of nonsteroidal antiinflammatory drugs with phospholipids comparison between octanol/buffer partition coefficients and chromatographic indexes on immobilized artificial membranes, J. Pharm. Sci. 86, 225-229 (1997). [Pg.267]

Ottiger, C. Wunderli-Allenspach, H., Immobilized artificial membrane (IAM)-HPLC for partition studies of neutral and ionized acids and bases in comparison with the liposomal partition system, Pharm. Res. 16, 643-650 (1999). [Pg.267]

Taillardat-Bertschinger, A. Martinet, C. A. M. Carrupt, P.-A. Reist, M. Caron, G. Fmttero, R. Testa, B., Molecular factors influencing retention on immobilized artificial membranes (IAM) compared to partitioning in liposomes and n-octanol, Pharm. Res. 19, 129-Til (2002). [Pg.267]

Avdeef, A. Strafford, M. Block, E. Balogh, M. P. Chambliss, W. Khan, I., Drug absorption in vitro model Filter-immobilized artificial membranes. 2. Studies of the permeability properties of lactones in piper methysticum forst, Eur. J. Pharm. Sci. 14, 271-280 (2001). [Pg.281]

Immobilized artificial membranes (IAM) are another means of measuring lipophilic characteristics of drug candidates and other chemicals [90-94], IAM columns may better mimic membrane interactions than the isotropic octanol/water or other solvent/solvent partitioning system. These chromatographic indices appear to be a significant predictor of passive absorption through the rat intestine [95]. [Pg.12]

I. Khan. Drug absorption in vitro model filter-immobilized artificial membranes. 2. Studies of the permeability properties of lactones in Piper methysticum Forst, Eur. [Pg.89]

Correlation to HAS and IAM column retentivity VD is a function of albumin binding and partitioning into phospholipid membranes, and these can be measured using affinity HPLC columns Retentivity on human albumin and immobilized artificial membrane HPLC columns [33]... [Pg.487]

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See also in sourсe #XX -- [ Pg.102 ]

See also in sourсe #XX -- [ Pg.39 ]

See also in sourсe #XX -- [ Pg.466 ]



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