Imipenem Aminoglycosides

Albrecht LM, Rybak MJ. Combination imipenem-aminoglycoside therapy. Drug Intell Clin Pharm ( 9S 20, 506. [Pg.290]

Cirrhosis Peritoneal Cefotaxime Regimen based on organism isolated 1. Add clindamycin or metronidazole if anaerobes are suspected 2. Other third-generation cephalosporins, extended-spectrum penicillins, aztreonam, and imipenem as alternatives 3. Aminoglycoside with antipseudomonal penicillin... [Pg.1135]

General Imipenem/cilastatin, meropenem, ertapenem, or extended-spectrum penicillins with 3-lactamase inhibitor 1. Aztreonam with clindamycin or metronidazole 2. Ciprofloxacin with metronidazole 3. Aminoglycoside with clindamycin or metronidazole ... [Pg.1135]

Pseudomonas Cephtazidime, cefepime, imipenem, aztreonatn, ciprofloxacin, aminoglycoside, and extended-spectrum penicillin... [Pg.15]

Cefepime,0 ceftazidime,0 piperadllin-tazobactam, or ticardllin-davulanate plus aminoglycoside Ciprofloxacin/ levofloxacin/ aztreonam/ imipenem," meropenem," or colistin... [Pg.394]

Infections resistant to other antibiotics (eg, cephalosporins, penicillins, aminoglycosides) have responded to treatment with imipenem. [Pg.1530]

Action Monobactam, -1- cell wall S5mth Dose Adul. 1—2 g IV/EM q6-12h Peds. Premature 30 mg/kg/dose IV ql2h Term children 30 mg/kg/dose q6-8h X in renal impair Caution [B, +] Disp Inj SE NA /D, rash, pain at inj site Interac tions T Effects W/probenecid, aminoglycosides, i-lactam antibiotics X effects W7 cefoxitin, chloramphenicol, imipenem EMS Monitor for S/Sxs of super Infxn may cause aUCTgic Rxns rare cross-sensitivity Rxns to penicillins and cephalosporins have been rqwrted OD May cause Szs symptomatic and supportive... [Pg.86]

Septicemia with granulocytopenia Any Antipseudomonal penicillin + aminoglycoside ceftazidime cefepime imipenem or meropenem consider addition of systemic antifungal therapy if fever persists beyond 5 days of empiric therapy ... [Pg.1104]

Gram-negative bacilli Acinetobacter Infections in various tissues hospital-acquired infections An aminoglycoside + ticarcillin Imipenem or meropenem ciprofloxacin trimethoprim-sulfamethoxazole ampi-cillin/sulbactam... [Pg.515]

Enterobacter species Urinary tract and other infections Aztreonam, imipenem, meropenem, or cefepime + an aminoglycoside Ciprofloxacin trimethoprim-sulfamethoxazole 3rd generation cephalosporin... [Pg.515]

Escherichia coli Bacteremia urinary tract infections other systemic infections 3rd-generation cephalosporin, ampicillin, amoxicillin/clavu-lanate, trimethoprim/sul-famethoxazole, or cephalexin An aminoglycoside ampi-cillin/sulbactam imipenem meropenem a fluoroquinolone 1st- or 2nd-generation cephalosporin... [Pg.515]

Klebsiella pneumoniae Pneumonia urinary tract infection 3rd-generation cephalosporin an aminoglycoside Cefuroxime ciprofloxacin ofloxacin ampicillin/ sulbactam amoxicillin/ clavulanate imipenem meropenem trimethoprim-sulfamethoxazole... [Pg.515]

Pseudomonas aeruginosa Bacteremia pneumonia Ceftazidime or piperacillin + an aminoglycoside Aztreonam cefepime ciprofloxacin imipenem meropenem... [Pg.516]

Pseudomonas aeruginosa Antipseudomonal penicillin + aminoglycoside5 Antipseudomonal penicillin + quinolone cefepime, ceftazidime, imipenem, or aztreonam aminoglycoside... [Pg.1171]

Imipenem or meropenem aminoglycoside° (amikacin usually most effective)... [Pg.381]

Many metabolites and compounds such as antibiotics penetrate cells via transport proteins and, as a result, mutation in these proteins or decrease in their expression can decrease antibiotic uptake. In Gram-negative bacteria, the outer membrane porins are required for entry of many antibiotics such as fS-lactams and aminoglycosides, and antibiotic resistance can occur through modulation of these proteins. For example, imipenem resistance... [Pg.96]

Clinically important, potentially hazardous interactions with amiloride, aminoglycosides, amphotericin B, ampicillin, anisindione, anticoagulants, armodafinil, atorvastatin, azathioprine, azithromycin, bacampicillin, basiliximab, bezafibrate, bosentan, bupropion, carbenicillin, caspofungin, cholestyramine, clarithromycin, cloxacillin, co-trimoxazole, corticosteroids, cyclophosphamide, daclizumab, danazol, dicloxacillin, dicumarol, digoxin, diltiazem, disulfiram, echinacea, erythromycin, ethotoin, etoposide, ezetimibe, flunisolide, fluoxymesterone, fluvastatin, foscarnet, fosphenytoin, gemfibrozil, hemophilus B vaccine, HMG-CoA reductase inhibitors, imatinib, imipenem/cilastatin, influenza vaccines, ketoconazole, lanreotide, lopinavir, lovastatin, mephenytoin, methicillin, methoxsalen, methylphenidate, methylprednisolone, methyltestosterone, mezlocillin, mizolastine, mycophenolate, nafcillin, nisoldipine, NSAIDs, orlistat, oxacillin, penicillins, phellodendron, phenytoin, pravastatin, prednisolone, prednisone, pristinamycin, ranolazine, red rice yeast, rifabutin, rifampin, rifapentine, ritonavir, rosuvastatin, simvastatin, sirolimus, spironolactone, St John s wort, sulfacetamide, sulfadiazine, sulfamethoxazole, sulfisoxazole, sulfonamides, tacrolimus, telithromycin, tenoxicam, testosterone, ticarcillin, tolvaptan, trabectedin, triamterene, troleandomycin, ursodeoxycholic acid, vaccines, vecuronium, warfarin, zofenopril... [Pg.152]

Early clinical trials showed no benefit from antibiotic prophylaxis, but studies were flawed, as they included patients with all degrees of disease severity and did not have a sufficient number of patients with severe necrotizing AP. " In addition, the studies utilized ampicillin, which does not penetrate well into pancreatic tissue." Imipenem-cilastatin, metronidazole, cefotaxime, piperacillin, mezlocillin, ofloxacin, and ciprofloxacin all achieve satisfactory bactericidal tissue concentrations, whereas aminoglycosides have poor penetration." " However, the importance of antibiotic penetration into pancreatic tissue has been debated, as it is the peripancreatic retroperitoneal necrotic fat and debris, not the pancreas itself, that becomes infected. [Pg.727]

It is incumbent on health professionals to avoid toxic drugs whenever possible. Antibiotics associated with CNS toxicities, usually when not dose-adjusted for renal function, include penicillins, cephalosporins, quinolones, and imipenem. Hematologic toxicities generally are manifested with prolonged use of nafcillin (neutropenia), piperacillin (platelet dysfunction), cefotetan (hypoprothrombinemia), chloramphenicol (bone marrow suppression, both idiosyncratic and dose-related toxicity), and trimethoprim (megaloblastic anemia). Reversible nephrotoxicity classically is associated with aminoglycosides... [Pg.1915]

TGC - (if UTI only Aminoglycoside ) Trimethoprim-sulfamethoxazole, cefuroxime," fluoroquinolone, BLIC, imipenem," or meropenem" Legionella spp. [Pg.1921]

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