Imaging techniques myocardial

Nuclear imaging techniques, like single photon emission tomography (SPECT) and positron emission tomography (PET), directly assess myocardial perfusion, cell membrane integrity, cellular metabolism, and the molecular mechanisms of ischemic viable or necrotic myocardium, thereby indicating revascularization procedures or not. 

The importance of ECG to detect myocardial ischaemia correlation with imaging techniques... 

Sobel et al. have published a series of reports on the use of labeled palmitic acid for metabolic studies using ECT techniques in animals and humans (12,13,14,57 58 59). Robinson et al. (16,17), Machulla et al. (18), and a few other investigators, have demonstrated the use of labeled with for perfusion studies and limited metabolic applications using conventional scintillation camera imaging systems. Myocardial uptake of similar compounds labeled with F and have also been reported (60,61,62). The many attempts... 

SPECT and PET imaging of myocardial perfusion have been used now for many years to assess myocardial perfusion and hemodynamic significance of coronary lesions. Although these techniques are still in use for clinical routine assessment, they also suffer from limitations ... 

The principle of todays myocardial perfusion imaging techniques, no matter what modality actually being used, is based on the comparison of stress and rest studies. This strategy actually rehably differentiates persistent from reversible myocardial perfusion deficits. Apphcation of this principle to CT techniques would in addition double the radiation dose. OveraU, these current limitations prohibit CT dynamic perfusion imaging being used in clinical appfications. 

With the advent of multidetector row techniques, CT has picked up DE again. Several studies have focused on comparison to DE-MRl and on the optimization of imaging techniques. Based on animal studies, it has been shown that DE-CT imaging basically has the same potential in delineation of myocardial viability (Amado et al. 2006 et al. Gerber 2006 Lardo et al. 2006). The clinical application of this technique though is hampered by the following factors ... 

ANS It was the velocity of the endocardium. With the digital imaging techniques, you can outline the myocardial walls, the inner and outer surface, and you can even add the left ventriculargram and the muscle shell at the same time. We conducted studies to determine the muscle volume. Then you can certainly delineate the endocardial and the epicardial surface of that ventricle in the projections which you choose. 

---