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Hyperparathyroidism Pancreatitis

The incidence of acute pancreatitis as a suspected complication of finasteride treatment has been examined in a case-control study in a Danish regional population of 490 000 over 7 years. Of 302 men aged 60 and older with incident acute pancreatitis, three had been exposed to finasteride of 2994 controls 37 had been exposed to finasteride. After adjustment for alcohol-related diseases, gallstone disease, hyperlipidemia, hypercalcemia, and hyperparathyroidism, the authors found no evidence of an increased risk of acute pancreatitis in users of finasteride (48). [Pg.153]

Calcitonin levels are also elevated in some patients with carcinoid and cancer of the lung, breast, Iddney, and liver. The usefulness of calcitonin as a tumor marker in these malignancies has not been proven. Calcitonin elevation has been reported in other nonmahgnant conditions, such as pulmonary disease, pancreatitis, hyperparathyroidism, pernicious anemia, Pagefs disease of bone, and pregnancy. [Pg.766]

Acute hemorrhagic and edematous pancreatitis Healing phase of bone disease of treated hyperparathyroidism, hyperthyroidism, and hematological malignancies (hungry bone syndrome)... [Pg.1894]

Acute symptomatic hypocalcemia may be seen in hospitalized patients for various reasons. Rapid remineralization of bone after surgery for primary hyperparathyroidism (hungry bone syndrome), treatment for hyperthyroidism, or treatment for hematological malignancy may result in hypocalcemia. Acute hemorrhagic or edematous pancreatitis is frequently complicated by hypocalcemia. Vitamin D deficiency may also be associated with hypocalcemia because of impaired intestinal absorption of calcium and skeletal resistance to PTH. Osteomalacia and rickets are discussed in a later section of this chapter. [Pg.1894]

There is epidemiologic evidence to suggest an increased prevalence of duodenal ulcers in patients with certain chronic diseases, but the pathophysiologic mechanisms of these associations are uncertain. A strong association exists in patients with systemic mastocytosis, multiple endocrine neoplasia type 1, chronic pulmonary diseases, chronic renal failure, kidney stones, hepatic cirrhosis, and ai-antitrypsin deficiency. An association may exist in patients with cystic fibrosis, chronic pancreatitis, Crohn s disease, coronary artery disease, polycythemia vera, and hyperparathyroidism. [Pg.632]

Hyperparathyroidism results from oversecretion of PTH. This condition leads to excessive bone turnover and demineralization and must be treated by removal of the parathyroid gland. The disorder is classified into primary, secondary, and tertiary hyperparathyroidism. Sporadic primary hyperparathyroidism is the third most common endocrine disorder, after diabetes and hyperthyroidism. It is most common in females older than 55 years of age and the leading cause is a single adenoma, which secretes the hormone constitu-tively, without regulation. Symptoms can include osteopenia and bone fractures, renal stones resulting from hypercalciuria, peptic ulcer disease, and pancreatitis. In milder cases, patients are asymptomatic or suffer only muscle weakness, fatigue, and/or depression. [Pg.457]

Acute hemorrhagic pancreatitis causes relatively minor serum alkaline phosphatase elevations, with values ranging from 4.0-13.5 Bodansky units/dl (K32) and a rough correlation between the severity of hyperbilirubinemia and the degree of hyperphosphatasemia (W16). Acute pancreatitis may be due to such disorders as alcoholism, gallstones, or hyperparathyroidism, which may themselves, by various mechanisms, give rise to serum alkaline phosphatase elevation (A4). [Pg.210]

MEN type I is characterized by hyperparathyroidism, together with pituitary and pancreatic tumours. Hyper-calcaemia caused by excess PTH. secretion is the dominant feature in this syn-drt)me. The most common pituitary tumour is a non-functioning chromophobe adenoma which, although it dws not secrete a hormone itself, may have effects on the secretion of other anterior pituitary hormones. The most common pancreatic tumour in MEN type 1 is an islet cell tumour secreting gastrin. The secretion of gastrin may lead to gastric ulceration. [Pg.49]

Tables 63-6.5 list some of the causes that affect plasma calcium, magnesium, and phosphate. Increased plasma calcium concentration may occur when the xeno-biotic specifically targets calcium metabolism, behaves similarly to vitamin D, and causes hyperparathyroidism or renal disease. Lead and cadmium enter bone and inhibit bone growth, increase calcium release from bone, and inhibit renal tubular reabsorption of calcium salts lead inhibits the renal bioactivation of 25-hydroxy-cholecaliciferol (Sauk and Somerman 1991). In longer-term studies, increased plasma calcium may be associated with tumor burden. Because roughly half of circulating calcium is bound to plasma albumin, hypercalcemia can also arise from dehydration. Hypoparathyroidism, pancreatitis, and renal disease can reduce plasma calcium. Acidosis increases plasma-ionized calcium concentrations, whereas alkalosis causes a decrease due to the effects of pH in the ECF or on protein binding. Tables 63-6.5 list some of the causes that affect plasma calcium, magnesium, and phosphate. Increased plasma calcium concentration may occur when the xeno-biotic specifically targets calcium metabolism, behaves similarly to vitamin D, and causes hyperparathyroidism or renal disease. Lead and cadmium enter bone and inhibit bone growth, increase calcium release from bone, and inhibit renal tubular reabsorption of calcium salts lead inhibits the renal bioactivation of 25-hydroxy-cholecaliciferol (Sauk and Somerman 1991). In longer-term studies, increased plasma calcium may be associated with tumor burden. Because roughly half of circulating calcium is bound to plasma albumin, hypercalcemia can also arise from dehydration. Hypoparathyroidism, pancreatitis, and renal disease can reduce plasma calcium. Acidosis increases plasma-ionized calcium concentrations, whereas alkalosis causes a decrease due to the effects of pH in the ECF or on protein binding.
Excessive amounts of parathyroid hormones can cause focal pancreatic necrosis. It is not known whether pancreatitis precedes hyperparathyroidism or vice versa, but it has been suggested that the pancreatitis leads to steatorrhea with hypocalcemia and secondary hyperparathyroidism. [Pg.352]

A disorder in which there are adenomas or hyperplasia occuring simultaneously in the pituitary, adrenals, pancreas, parathyroids or in any combination of these glands. The symptoms therefore include hyperparathyroidism, acromegaly, Cushing s syndrome, gastric ulceration (if the pancreatic cells produce... [Pg.247]


See other pages where Hyperparathyroidism Pancreatitis is mentioned: [Pg.414]    [Pg.352]    [Pg.357]   
See also in sourсe #XX -- [ Pg.352 ]




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