Hyperlipidemic agents

Male rats treated with either clofibrate [2-(p-chloro-phenoxy)-2-methyl-propionic acid ethyl ester] or nafenopin [2-methyl-2-(p-l,2,3,4-tetrahydro-l-naph-thyl)phenoxypropionic acid], two peroxisome proliferating compounds with potent hypoHpidemic properties, showed identical structural changes in their lungs (Fringes and Reith 1988). 

The size of the type II pneumocytes was conspicuously increased by about 30 % in Lewis rats treated with 300 mg clofibrate/kg body weight x day by in-traperitoneal injections for 7 days (Fringes and Reith 1988). Peroxisomes proliferated and there was an increase in the number of surfactant-rich lamellar bodies (Fringes et al. 1988). 

Bezafibrate 2-[p-[2-(p-chlorobenzamido)ethyl]phenoxy]-2-methylpropionic acid 

Fenofibrate isopropyl[4 (p-chlorobenzoyl)-2-plienoxy-2-methyl]propionate 

Nafenopin 2-methyl-2-[p-(l,2,3,4-tetrahydro-l-naphthyl)phenoxy]propionic acid 

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Sato B, Nakajima H, Fujita T, Takase S, Yoshimura S, Kinoshita T, Terano H (2005) FR177391, a New Anti-Hyperlipidemic Agent from Serratia 1. Taxonomy, Fermentation, Isolation, Physico-Chemical Properties, Structure Elucidation and Biological Activities. J Antibiot 58 634... 

Alder R, Lookinland S, Berry JA, Williams M (2003) A systematic review of the effectiveness of garlic as an anti-hyperlipidemic agent. J Am Acad Nurse Pract 15(3) 120-129... 

I. In Vivo Assay of Hypolipidemic Agents Using Hyperlipidemic Hamsters... 

Antilipidemic Agents. The administration of clofibrate leads to a significant decrease in serum alkaline phosphatase both in hyperlipidemic and in normolipidemic patients (F5, S8, W18). Isoenzyme analysis shows that this change is entirely attributable to a reduction in the circulating liver enzyme (W18). 

Boissonnat P, Salen P, GuidoUet J, Ferrara R, Dureau G, Ninet J, Renaud S, de Lorgeril M. The long-term effects of the lipid-lowering agent fenofiNate in hyperlipidemic heart transplant recipients. Transplantation (1994) 58,245-7. 

It is often difficult to manage hyperlipidemia in FHC with standard dietary management. Specific fibers in appropriate amounts exert a pronounced hypolipidemic effect in man and animals. Pectin and Guar have been especially effective in lowering cholesterol in normal and hyperlipidemic patients.10-H However, not all fibers are effective in iowering lipids. No two sources of dietary fiber have the same effect on lipid metabolism. 2 Some dietary fibers, although effective as hypolipidemic agents, are not palatable or are difficult to incorporate into food because of increased viscosity or other chemical or taste properties. 

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