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Hydroxypropyl methylcellulose properties

Hydroxypropyl methylcellulose phthalate Synonyms HPMCP Hypromellose phthalate Definition A monophthalic acid ester of hydroxypropyl methylcellulose Properties Wh. powd., odorless, tasteless pract. insol. in water... [Pg.2142]

A radiotelemetric method has been described to test the disintegration property of a tablet [58], A tablet containing a citrate buffer was coated with hydroxypropyl methylcellulose phthalate and then placed in a Heidelberg capsule that also contained a pH-electrode (Figure 8). An antenna is strapped around the midriff of the dog to detect the output from the Heidelberg capsule. [Pg.28]

Sarkar, N. (1979). Thermal gelation properties of methyl and hydroxypropyl methylcellulose. /. Appl. Polym. Sci. 24 1073-1087. [Pg.215]

A popular approach to improve ocular drag bioavailability is to incorporate soluble polymers into an aqueous solution to extend the drug residence time in the cul-de-sac. It is reasoned that the solution viscosity would be increased and hence solution drainage would be reduced. The more commonly used viscolyzing agents include PVA and derivatives of cellulose. Cellulosic polymers, such as methylcellulose, hydroxyethylcellulose (HEC), hydroxypropyl-methylcellulose (HPMC) and hydroxypropylcellulose (HPC), are widely used as viscolyzers showing Newtonian properties. They have common properties ... [Pg.308]

Substituted Cellulose Ethers. Since their introduction for ophthalmic use, MC and other substituted cellulose ethers such as hydroxyethylcellulose, hydroxypropylcel-lulose, hydroxypropyl methylcellulose (HPMC), and carboxymethylcellulose (CMC) have been used in artificial tear formulations.These colloids dissolve in water to produce colorless solutions of varying viscosity. They have the proper optical clarity, a refractive index similar to the cornea, and are nearly inert chemically. Their relative lack of toxicity, their viscous properties, and their beneficial effects on tear film stability have made cellulose ethers useful components of artificial tear preparations. Historically, the most frequently used representative of this group was MC. [Pg.266]

Johnson, K. Hathaway, R. Leung, P. Franz, R. Effect of triacetin and polyethylene glycol 400 on some physical properties of hydroxypropyl methylcellulose free films. Int. J. Pharm. 1991, 73, 197-208. [Pg.1745]

Lehtola, V.-M. Heinamaki, J.T. Nikupaavo, P. Yliruusi, J.K. The mechanical and adhesion properties of aqueous-based hydroxypropyl methylcellulose coating systems containing polydextrose and titanium dioxide. Drug Dev. Ind. Pharm. 1995, 21 (6), 675-685. [Pg.1745]

Fig. 27 Infiuence of the type of polymer application on film properties (top and side view). HP55 (HPMCP)-coated pellet, prepared from a micronized film dispersion (A). HP55 [hydroxypropyl methylcellulose (HPMCP)]-coated pellet, prepared from an organic solution (B). Fig. 27 Infiuence of the type of polymer application on film properties (top and side view). HP55 (HPMCP)-coated pellet, prepared from a micronized film dispersion (A). HP55 [hydroxypropyl methylcellulose (HPMCP)]-coated pellet, prepared from an organic solution (B).
Katzhendler, I. Mader, K. Friedman, M. Structure and hydration properties of hydroxypropyl methylcellulose matrices containing naproxen and naproxen sodium. Int. J. Pharm. 2000, 200, 161-179. [Pg.3751]

Dahl TC, Calderwood T, Bormeth A, et al. Influence of physicochemical properties of hydroxypropyl methylcellulose on naproxen release from sustained release matrix tablets. / Control Release 1990 14 1-10. [Pg.349]

Rosoff M, Sheen P-C. Pan abrasion and polymorphism of titanium dioxide in coating suspensions. ] Pharm Sci 1983 72 1485. Lehtola VM, Heinamaki JT, Nikupaavo P, Yliruusi JK. Effect of titanium dioxide on mechanical, permeability and adhesion properties of aqueous-based hydroxypropyl methylcellulose films. Boll Chim Farm 1994 133(Dec) 709-714. [Pg.784]

Mitchell A, Reynolds TD, Dasbach TP. A cpoorly water-soluble drugs using hydroxypropyl methylcellulose, Int J Pharm 2003 250 3-11. Rambali B, Bacrt L. Jans E. Masscart DL. Influence of the roll compactor parameter settings and the compression pressure on the buccal bio-adhesive properties. Int J Pharm 2001 220 129. ... [Pg.333]

Rowe RC. The effect of molecular weight on the properties of films prepared from hydroxypropyl methylcellulose. Hiarm Acta Helv 1976 5l(ll) 330-4. [Pg.410]

Katzhendler I, Mader K, Azoury R, et al. Investigating the structure and properties of hydrated hydroxypropyl methylcellulose and egg albumin matrices containing caihamazepine EPR and NMR study. Pharm Res 2000 17(10) 1299-1308. [Pg.418]

Nisin was also added to films made from hydroxypropyl methylcellulose (HPMC), a cellulose derivative. Glycerol was added to the HMPC-nisin film to serve as a plasticizer to improve the material s mechanical property. The HMPC-nisin-glycerol films exhibited antimicrobial effects against Listeria, Enterococcus, Staphylococcus and Bacillus spp. Mechanical tests revealed that the films have reduced tensile strength but have increased ultimate elongation. [Pg.76]

When hydroxypropyl methylcellulose is dissolved in water, colloids are formed. The compound is nontoxic but with oxidizing agents it is combustible. Unlike methylcellulose, hydroxypropyl methylcellulose in an aqueous solution, displays a thermal gelation property.This happens when the solution is heated up to a critical temperature the solution congeals into a nonflowable but semi-flexible mass. Typically, this critical temperature point is inversely related to (1) the solution concentration and (2) the concentration of the methoxy group within the hydroxypropyl methylcellulose molecule. ... [Pg.621]

Brindle, L.P., Krochta, J.M. 2008. Physical properties of whey protein hydroxypropyl methylcellulose blend edible films. Journal of Food Science, 73(9) 446-454. [Pg.828]

Imran, M., El-Fahmy, S., Revol-Junelles, A.M., Desobry, S. 2010a. Cellulose derivative based active coatings Effects of nisin and plasticizer on physico-chemical and antimicrobial properties of hydroxypropyl methylcellulose films. Carbohydrate Polymers, 81 219-225. [Pg.830]

Chemg A, Takagi S, Chow LC. Effects of hydroxypropyl methylcellulose and other gelling agents on the handling properties of calcium phosphate cement. J Biomed Mater Res. 1997 Jun 5 35(3) 273-7. [Pg.41]

S. Devjak Novak, et al.. Characterization of physicochemical properties of hydroxypropyl methylcellulose (HPMC) type 2208 and their influence on prolonged drug release from matrix tablets, /. Pharmaceut. Biomed., 66,136-143,2012. [Pg.238]

B. Cappello, C. di Maio, M. lervolino, and A. Miro, Combined effect of hydroxypropyl methylcellulose and hydroxypropyi p-cyclodextrin on physicochemical and dissolution properties of celecoxib, /. Incl. Phenom. Macrocycl. Chem., 59,237-244,2007. [Pg.437]

Grafting of hydroxypropyl methylcellulose (HPMC) with acrylic acid to yield biodegradable and biocompatible copolymers-like hydrogel with improved properties was performed [34] to enhance drug activity and to reduce the frequency of the doses. The product was prepared by in situ emulsifier free emulsion polymerization through one-stage grafting. So, acrylic acid could intercalate into layers of HPMC... [Pg.92]

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See also in sourсe #XX -- [ Pg.438 ]



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