Hydrophobic and hydrogen-bonding

Bioadhesion to the vaginal substrate implies knowledge and demonstration of the mechanism of interaction. In the present case, mucoadhesion, bioadhesion, and substantivity can be used interchangeably when evaluating the mucosa as a substrate. Several forces may be active, such as electrostatic, hydrophobic, and hydrogen bonding, giving rise to surface interactions between the polymer and the mucosal substrate or diffusion into the mucus layer [48,49]. 

Finally, the use of a u-polarity field instead of different and more empirical electrostatic, hydrophobic, and hydrogen-bonding fields should lead to considerable advantages in molecular field analysis (MFA) techniques such as ComFA. On the one hand, a includes all three aspects of interactions in a single field, and on the other hand, this interaction picture meanwhile is much better validated quantitatively than the empirical fields presently used in MFA. The only problem here is that a is a surface property and thus less a field in space. With some effort it should be possible to develop reasonable functions for the extension of a perpendicular to the molecular surface and thus to generate a kind of 3D a-filed as required for MFA. 

They bind mono- or oligo-saccharides with remarkable specificity, in the same way as enzymes bind substrates and antibodies bind antigens. Binding may involve several forces, mostly hydrophobic and hydrogen bonds, and is competitively inhibited by specific sugars. 

Analysis of the crystallographic structure also reveals that the two domains interact primarily through hydrophobic and hydrogen bond interactions at the interface. The number of apolar hydrogens that become exposed on the C domain on unfolding of the N domain is 49.4, and the number of apolar hydrogens exposed on the N domain on unfolding of the C domain is 44.8. These values correspond to 726 and 659 A2 of apolar surface area, respectively. In addition, nine... 

Nanoparticles are unstable under strongly acidic conditions. Indeed, NPs protected by a mixed monolayer composed of a 1 1 mixture of dodecanethiolate and triethylene glycol thiolates aggregate under strongly acidic conditions. Interestingly, these authors reported that the acid induces the formation of clusters of these MPCs and that the extent and the rate of cluster formation is the result of a subtle balance between hydrophobic and hydrogen bonding interactions between particles and between the particles and the solvent.157... 

Steric, Hydrophobic, and Hydrogen-Bonding Properties of Ligand Binding Sites in Proteins... 

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