Hydrobromie acid

By the action of bromine on nicotine in hydrobromie acid, dibro-moticonine (Formula B), CjoHgOaNjBrj, nodular crystals, m.p. 196°, is obtained. This with zinc dust in warm alkali yields methylamine and pyridyl- y-dihydroxybutyrie acid,... 

From this salt the bromide, [Cr en2pn]Br3.3H20, is prepared by decomposing it with concentrated aqueous hydrobromie acid. A finely crystalline precipitate separates, which is recrystallised from water and alcohol in glistening yellow clusters. 

Chloro - aquo - tetrammino - chromic Bromide, [Cr(NHa)4 (H20)ClJBr2, is precipitated from a solution of the chloride on the addition of hydrobromie acid it forms violet-red octahedral crystals which are soluble in water, giving a red solution. 

The bromide, [Co en2(H20)2]Br3.2H20, is formed in the same manner by the aetkn of concentrated hydrobromie acid. It crystallises in shining red plates which dissolve in -water, giving an intensely red solution which is acid in reaction.2... 

The bromide, [Co en2H20.0H]Br2.H20, is obtained from the chloride or from iraws-dichloro-diethylenediamino-cobaltic chloride by treating it with concentrated aqueous potassium hydroxide and, after cooling to 0° C., neutralising the solution obtained with concentrated hydrobromie acid. It is a red crystalline powder, and resembles the chloride in properties. 

The bromide, [Co en2H2O.OH]Br2, is obtained in a similar manner, or from the cis-salt by boiling the aqueous solution with potassium hydroxide for a short time and neutralising the solution with well-cooled hydrobromie acid. It is a light red powder, and is less soluble in water than the chloride. 

It separates in small violet rhombic crystals which resemble chloro-pentammino-cobaltic chloride in appearance. It is soluble in cold water to a certain extent, and only two-thirds of the chlorine is precipitated from solution by silver nitrate at ordinary temperature. In aqueous solution the salt is gradually transformed into the diaquo-salt, [Co(NH3)4(HaO)2]Cl3 dilute nitric acid, if rubbed with the substance, gives reddish-violet crystals of the nitrate, [Co(XH3)4(HaO)Cl](NOs)2 and a cold concentrated solution of ammonium sulphate yields the sulphate, [Co(NH3)4(H20)C1]S04. The corresponding bromide, [Co(NH3)4(H2Q)Cl]Br2, is obtained by filtering a cold saturated solution of the chloride into concentrated hydrobromie acid at 0° C. The precipitate formed is washed with hydrobromie acid and then with alcohol. The bromide is almost insoluble in hydrobromie acid, but more easily soluble in water than the chloride.2... 

Bromo-aquo-tetrammino-cobalticBromide,[Co(NH3)4H2O.Br] Br , may be prepared by warming dibromo-tetrammino-cobaltic bromide, [Co(NII3)4Br2]Br, with water and a little hydrobromie acid. It crystallises in brownish-violet prisms.3... 

A solution of chloro-diaquo-triammino-cobaltic bromide is blue in colour, and on the addition of hydrobromie acid the isomeric chloro-bromo-aquo-triammino-eobaltic bromide monohydrate, [Co(NH3) 3(H 20) ClBr]Br.H20, separates in brown needles even at temperatures below... 

Hexammino-iridium Bromide, [Ir(NII3)6]Br3, is formed by treating a solution of the nitrate with hydrobromie acid. It crystallises in colourless six-sided prisms which resemble the chloride, only they are more soluble in water. 

Gutbier1 prepared pure brom-platinic add by repeatedly evaporating the pure chloride with concentrated hydrobromie acid on the water-bath and then treating it similarly three or four times with hydro-bromic acid containing bromine. The residue, on being taken up with dilute hydrobromie add, yields a deep carmine-red solution. 

These salts are isomorphous with the chlor-platinates already described, and which they resemble in their general chemical reactions. The alkali salts are best known, and are readily prepared by addition of a solution of the alkali bromide to one of brom-platinic acid, and crystallising the precipitated complex from dilute hydrobromie acid.3... 

The solubilities of the alkali brom-platinates in water and dilute hydrobromie acid decrease with increasing atomic weight of the alkali metal. The solutions obtained are red in colour, but turn yellow on dilution with water. Hydrazine hydrate decomposes them with ease, metallic platinum being deposited and nitrogen evolved. 

The hydrolysis is complete and gives phosphorous and hydrobromie acids. The heat of hydrolysis was found to be 64-1 Cals.,1 i.e. nearly the same as that of PC13. 

General Reactions.—Various products were obtained when phosphorous acid was heated with halogens in a sealed tube. Iodine gave phosphoric and hydriodie acids, phosphonium iodide and an iodide of phosphorus, whilst bromine gave phosphoric acid, phosphorus tribromide and hydrobromie acid.6 A dry ether solution of the acid was not oxidised by bromine or dry palladium black, but oxidation proceeded readily in the presence of moisture.7... 

The arsenoxide reacts with the hydrobromie acid from (1) as follows ... 

Bis(10-bromo-5 10-dihydrophenarsazine) is prepared by Method (3) given for the preceding compound, the hydrochloric acid being replaced by hydrobromie acid. 

Thebaine is dissolved in aqueous formic acid and treated with 30% H O neutralization with aqueous ammonia gives 14-hydroxycodeinone. It is hydrogenated to give oxycodone. 90 ml of concentrated hydrobromie acid are heated to 90°C. 9 grams of 14-hydroxydi-hydrocodeinone (oxycodone) are then added under stirring and the mixture is quickly heated to 116°C and kept at this temperature under reflux condenser for 20 minutes, with continued stirring. The resulting brown solution is diluted with about 90 ml of water and chilled with ice. Aqueous 10% sodium hydroxide solution is now added to alkaline reaction and the liquid is extracted 3 times with 100 cc portions of chloroform. The layers are separated and the aqueous phase is filtered and acidified by the addition of concentrated aqueous hydrochloric acid, treated with charcoal and filtered. 

The 1,3-propanediol (trimethylene glycol) was obtained as a byproduct of the soap industry, where it exists as a minor impurity in the glycerol. However, both 1,3-propanediol and hydrobromiic acid are relatively expensive compared to propane and chlorine." Hass process made the production of cyclopropane more cost effective. 

---