Humatin

Trade Name(s) D Humatin (Parke Davis) GB Humatin (Parke Davis) Paramicina (Ragionieri)... 

The aminoglycoside paromomycin Humatin) has a mode of action identical to that of the other aminocycli-tols and is directly amebicidal. It is not absorbed from the intestinal tract and thus has its primary effect on bacteria, some amebas (e.g., E. histolytica), and some helminths found in the lumen of the intestinal tract. Side effects are limited to diarrhea and gastrointestinal upset. 

Oral 500 mg tablets, powder for 100 mg/5 mL oral solution Paromomycin (Humatin)... 

Clinical Use. Paromomycin (Humatin) is an aminoglycoside antibacterial (see Chapter 33) that is used primarily to treat mild to moderate intestinal infections (amebiasis).51 This drug may also be used as an adjunct to other amebicides during the treatment of more severe protozoal infections. Paromomycin is also effective against some bacteria and tapeworms, and may be used as a secondary agent in certain bacterial or helminthic infections. This drug is administered orally. 

Paromomycin Sulfate, USP. The isolation of paromomycin (Humatin) was reported in I9S6 from a fermentation with a Streptomyces sp. (PD 04998), a strain said to resemble 5. rimostis very closely. The parent organism had been obtained from soil samples collected in Colombia. Paromomycin. however, more closely re.sembles neomycin and streptomycin in antibiotic activity than it dtx s oxytetracycline, die antibiotic obtained from S. rintosus. 

Trade names Gabbroral Gabroral Humagel Humatin (Monarch) (Sanofi-Aventis) Sinosid Indications Intestinal amebiasis Category Antibiotic, aminoglycoside Half-life N/A... 

Acute intestinal amebic dysentery is most commonly treated with metronidazole (1, Flagyl) (Table 1). An alternative drug is iodoquinol (2, diiodohydroxyquin, diiodohydroxyquinoline [83-73-8]), which has also been used advantageously in combination with metronidazole or oxytetracydine (3, Terramycin [79-57-2]). For patients too sick to take iodoquinol orally, emetine (4) or dehydroemetine (5, 2,3-dehydroemetine) hydrochloride is administered either subcutaneously or intramusculady. The latter sometimes is followed by chloroquine (6, Aralen) phosphate or iodoquinol. Because emetine and dehydroemetine cause cardiac arrhythmias, muscle weakness, and inflammation at the injection site, these toxic compounds are used primarily for patients whose lives are threatened by the disease. Antibiotics, such as tetracycline (7, Achromycin [60-54-8]) and paromomycin (8, Humatin), are also effective against moderate intestinal amebiasis. 

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