Humans major histocompatibility complex-associated

The role of the immune system in the pathophysiology of Graves disease is well established. A considerable amount of information links the human major histocompatibility complex (human leukocyte antigen [HLA]) with Graves disease. For instance, several HLA types, such as HLA-B8 and HLA-DR3, are associated with this disorder. Graves disease in the Japanese has been found to be associated with HLA-B35, whereas in patients of Chinese... 

Family history of RA. Genetic studies demonstrate a strong correlation between RA and the presence of major histocompatibility complex class II human leukocyte antigens (HLA), specifically HLA-DR1 and HLA-DR4.4,5 HLA is a molecule associated with the presentation of antigens to T lymphocytes. 

The MHC proteins are named after the "major histocompatibility complex —the DNA segment that codes for them. Human MHC proteins are also known as HLA antigens ( human leukocyte-associated antigens). Their polymorphism is so large that it is unlikely... 

Pociot F, Briant L, Jongeneel CV, Molvig J, Worsaae H, Abbal M, Thomsen M, Nerup J, Cambon-Thomsen A (1993) Association of tumor necrosis factor (TNF) and class II major histocompatibility complex alleles with the secretion of TNFa and TNFp by human mononuclear cells a possible link to insulin-dependent diabetes mellitus. Eur J Immunol, 23 224-231. 

Fig. 1. Schematic diagram of the major histocompatibility complex on human chromosome 6. Fully expressed genes are shown in black pseudogenes (which do not express a product) are shown in white and genes of undefined or uncertain status are shaded. Distances along the chromosome are measured in units known as kilobase pairs (kbp). BAT indicates B-associated transcript TNF, tumor necrosis factor. Adapted fiom Peter and Hawkins (P3) with permission, Copyright 1992, American Medical Association.

Androlewicz MJ, Anderson KS. Cresswell P (1993) Evidence that transporter associated with antigen processing translocate a major histocompatibility complex class I-binding peptide into the endoplasmic reticulum in an ATP-dependent manner. Proc Natl Acad Sci USA 90 91.30- 9134 Androlewicz MJ, Cresswell P (1994) Human transporters associated with antigen processing possess a promiscuous peptide binding site. Immunity 1 7 14... 

Bamd, D. L., Lan, M. S., Metzgar, R. S., and Finn, O. K., 1989, Specific major histocompatibility complex-unrestricted recognition of tumor-associated mucins by human cytotoxic T cells, Proc. Natl. Acad. Sci. USA 86 7159-7163. 

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