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Humanised antibodies

D. S. Ashton, C. R. Beddell, D. J. Cooper, and A. C. Lines, Determination of carbohydrate heterogeneity in the humanised antibody CAMPATH 1H by liquid chromatography and matrix-assisted laser desorption ionisation mass spectrometry, Anal. Chim. Acta, 306 (1995) 43 18. [Pg.131]

Alemtuzumab (MabCampath ) is also used to target the CDw52 receptor (CAMPATH1 antigen) on B lymphocytes, thus reducing their numbers in cases of chronic lymphocytic leukaemia. It is a humanised antibody where the some of the murine protein in the variable region has been replaced by human protein. [Pg.573]

Bevacizumab (Avastin ) is a humanised antibody produced in CHO cells used as first-line treatment for patients with colorectal cancer. [Pg.573]

Efalizumab (Raptiva ) is humanised antibody used to treat psoriasis which binds to the LFA-1 integrin protein which is expressed on all leucoc5ttes, thus inhibiting adhesion of leucocytes to the walls of blood vessels. Problems can occur in the use of antiprotein antibodies due to the following factors ... [Pg.574]

Margolin K, Gordon M, Holmgren E. Phase lb trial of intravenous recombinant humanised monoclonal antibody to vascular endothelial growth factor in combination with chemotherapy in patients advanced cancer Pharmacologic and long term results. J Clin Oncol 2001 19 851-859. [Pg.345]

A. Card, 6, Barbanti, P, R. Tempest, F, I. Carr, snd F, Marcucci. tdlatopedetermining regions of s mouse monoclonal antibody and its humanised version. / MoL BioL 235 53-60(1994),... [Pg.97]

Norman DJ, Vincenti F, DeMattos AM, Barry JM, Levitt DJ, Wedel NI, Maia M, Light SE. Phase 1 trial of HuM291, a humanised anti-CD3 antibody, in patients receiving renal allografts from living donors, Transplantation 2000 70 1707-12. [Pg.356]

These drugs fall into two types soluble TNF-a receptors, such as etanercept, and humanised monoclonal antibodies against TNF-a. Etanercept is a fusion... [Pg.335]

Kips JC, O Conner BJ, Langley SJ, Woodcock A, Kerstjens HAM, Postma DS, Danzig M, Cuss F and Pauwels RA. Effect of SCH55700, a humanised anti-human interleukin-5 antibody in severe persistent asthma - a pilot study. Am. J. Resp. Crit. Care. Med. 2003 167 1655-1659. [Pg.2332]

Clark M. Antibody humanisation for therapeutic applications. Cambridge, UK Cambridge University 2000. (Internet at www.path.cam.ac.uk/ mrc7/ humanisa tion/index. h tml.)... [Pg.497]

D. E. Allison, S. G. Gourlay, E. Koren, R. M. Miller, and J. A. Fox, Pharmacokinetics of rhuMAb CD18, a recombinant humanised monoclonal antibody fragment to CD18, in normal healthy human volunteers. Biodrugs 16 63-70 (2002). [Pg.1151]

Boeckh M, Berrey MM, Bowden RA et al. (2001). Phase I evaluation of the RSV-specihc humanised monoclonal antibody pahvizumab in hematopoietic stem cell transplant recipients. J Infect Dis, 184, 350-354. [Pg.463]

In vitro and in vivo anti-tumor effects of a humanised monoclonal antibody against c-erbB-2 product. Br J Cancer 1996, 73, 1362-1365. [Pg.161]

A 3-year-old girl who had been clinically stable on tocilizumab (humanised anti-IL6 receptor monoclonal antibody) had a relapse of JIA symptoms 7 days after an influenza vaccine [56 ]. [Pg.472]

The scope of the following proposal is limited to murine, chimeric, or humanised MAbs. Fully humanised MAbs are now entering development but as yet little data are available. Immimo-toxins and radiolabelled antibodies are not considered, since any inherent toxicity of the molecule linked to the antibody adds another dimension to the safety assessment of such products. [Pg.105]

See other pages where Humanised antibodies is mentioned: [Pg.242]    [Pg.108]    [Pg.572]    [Pg.572]    [Pg.242]    [Pg.108]    [Pg.572]    [Pg.572]    [Pg.618]    [Pg.931]    [Pg.1022]    [Pg.717]    [Pg.54]    [Pg.59]    [Pg.61]    [Pg.67]    [Pg.73]    [Pg.9]    [Pg.460]    [Pg.411]    [Pg.618]    [Pg.931]    [Pg.1022]    [Pg.84]    [Pg.194]    [Pg.176]    [Pg.8]    [Pg.390]    [Pg.51]    [Pg.139]    [Pg.211]    [Pg.577]    [Pg.578]    [Pg.579]    [Pg.704]    [Pg.105]   
See also in sourсe #XX -- [ Pg.571 ]



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