Human immunodeficiency virus identification

Deng H, Liu R, Ellmeier W, Choe S, Unutmaz D, Burkhart M, Di Marzio P, Marmon S, Sutton RE, Hill CM, Davis CB, Peiper SC, Schall TJ, Littman DR, Landau NR (1996) Identification of a major co-receptor for primary isolates of HIV-1. Nature 381 661-666 Derdeyn CA, Decker JM, Sfakianos JN, Wu X, O Brien WA, Ratner L, Kappes JC, Shaw GM, Hunter E (2000) Sensitivity of human immunodeficiency virus type 1 to the fusion inhibitor T-20 is modulated by coreceptor specificity defined by the V3 loop of gpl20. J Virol 74 8358-8367... 

Sei S., Yang Q.E., O Neill D., Yoshi-mura K., Mitsuya H. Identification of a key target sequence to block human immunodeficiency virus type 1 replication within the gag-pol transframe domain. 

Nath A, Psooy K, Martin C, Knudsen B, Magnuson DS, Haughey N, Geiger JD (1996) Identification of a human immunodeficiency virus type 1 Tat epitope that is neuroexcitatory and neurotoxic. J Virol 70(3) 1475-1480... 

Brelot A, Heveker N, Montes M, Alizon M. Identification of residues of CXCR4 critical for human immunodeficiency virus coreceptor and chemokine receptor activities. J Biol Chem 2000 275(31) 23736-23744. 

Hwang SS, Boyle TJ, Lyerly HK, Cullen BR (1991) Identification of the envelope V3 loop as the primary determinant of cell tropism in HIV-1. Science 253 71—74 Imai K, Okamoto T (2006) Transcriptional repression of Human Immunodeficiency Virus Type 1 by AP-4. J Biol Chem 281 12495-12505... 

Lutzke, R.A.P., Eppens, N.A., Weber, P.A., Houghten, R.A., and Plasterk, R.H.A. Identification of a hexapeptide inhibitor of the human immunodeficiency virus integrase protein... 

Gu Z, Gao Q, Fang H, Salomon H, Pamiak MA, Goldberg E, et al. Identification of a mutation of codon 65 in the IKKK motif of reverse transcriptase that encodes human immunodeficiency virus resistance to 2, 3 -dideoxycytidine and 2, 3 -dideoxy-3 -thiacytidine. Antimicrob Agents Chemother 1994 38 275-281. 

Engelman A, Craigie R. Identification of conserved amino acid residues critical for human immunodeficiency virus type 1 integrase function in vitro. J Virol 1992 ... 

Vink C, Oude Groeneger AAM, Plasterk RHA. Identification of the catalytic and DNA-binding region of the human immunodeficiency virus type 1 integrase protein. Nucl Acids Res 1993 21 1419-1425. 

The antitumor activities of JV-substituted 11 -oxo-11 //-pyrido[2,l -b]-quinazoline-6-carboxamides were studied (88JMC707 92MI3 95JMC2418). Using an automated pharmacophore identification procedure, 11-oxo-11//-pyrido[2,l-h]quinazoline-6-carboxamide (407) was predicted to be an active inhibitor of human immunodeficiency virus type 1 (HIV-1) integrase (97JMC920). 

In a more recent continuation of these studies, Campiani and co-workers carried out semi-empirical calculations on a series of active compounds related to 2. This led to the identification of several structural and conformational features responsible for this activity <2005JME4367>. Docking into the human immunodeficiency virus 1 (HIV-1) reverse transcriptase non-nucleotide binding site (RT NNBS) of a compound of type 3 (X = O) highlighted that one of the phenyl rings of this compound protrudes toward the catalytic site <2005JME7153>. 

Cochrane, A.W., Perkins, A. and Rosen, C.A. (1990) Identification of sequences important in the nucleolar localization of human immunodeficiency virus Rev relevance of nucleolar localization to function. J. Virol, 64, 881-885. 

Debnath AK, Radigan L, Jiang S (1999) Structure-based identification of small molecule antiviral compounds targeted to the gp41 core structure of the human immunodeficiency virus type 1. J Med Chem 42 3203-3209... 

Jenkins, T.M., Hickman, A. B., Dyda, F., Ghieiando, R., Davies, D.R., Ceaigie, R., Catalytic domain of human immunodeficiency virus type 1 integrase identification of a soluble mutant by systematic replacement of hydrophobic residues. 

Poeschla E, Gilbert J, Li X, Huang S, Ho A, Wong-Staal F. 1998. Identification of a human immunodeficiency virus type... 

Shang, F., Huang, H., Revesz, K., Chen, H.-C., Herz, R., and Pinter, A. (1991) Characterization of monoclonal antibodies against the human immunodeficiency virus matrix protein pl7 identification of epitopes exposed at the surfaces of infected cells. J. Virol. 65,4798-4804. 

Blair WS, Cao J, Jackson L et al (2007) Identification and characterization of UK-201844, a novel inhibitor that interferes with human immunodeficiency virus type 1 gpl60 processing. Antimicrob Agents Chemother 51 3554-3561... 

Regueiro-Ren A (2012) Inhibitors of Human Immunodeficiency Virus Type (HIV-1) attachment IX. Structure-activity relationships associated with 4-Fluoro-6-azaindole derivatives leading to the identification of l-(4-Benzoyl-piperazin-l-yl)-2-(4-fluoro-7-[l,2,3]triazol-l-yl-lH-pyrrolo[2,3-c]pyridin-3-yl)-ethane-l,2-dione (BMS-585248) (Manuscript in preparation)... 

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