Human immunodeficiency virus entry inhibitors

Madani N, Perdigoto AL, Srinivasan K et al (2004) Localized changes in the gp 120 envelope glycoprotein confer resistance to human immunodeficiency virus entry inhibitors BMS-806 and 155. J Virol 78 3742-3752... 

Lu RJ, Tucker JA, Zinevitch T et al (2007) Design and synthesis of human immunodeficiency virus entry inhibitors sulfonamide as an isostere for the a-ketoamide group. J Med Chem 50 6535-6544... 

Lu R-J, Tucker JA, Pickens J et al (2009) Heterobiaryl human immunodeficiency virus entry inhibitors. J Med Chem 52 4481 1487... 

Ho HT, Fan L, Nowicka-Sans B, McAuhffe B, li CB, Yamanaka G, Zhou N, Fang H, Dicker 1, Dalterio R, Gong YF, Wang T, Yin Z, Ueda Y, MatiskeUa J, Kadow J, Qapham P, Robinson J, Colonno R, Lin PF (2006) Envelope conformational changes induced by human immunodeficiency virus type 1 attachment inhibitors prevent CD4 binding and downstream entry events. 

Jacobson JM, Lowy 1, Fletcher CV, O NeUl TJ, Tran DN, Ketas TJ, Trkola A, Klotman ME, Maddon PJ, Olson WC, Israel RJ (2000) Single-dose safety, pharmacology, and antiviral activity of the human immunodeficiency virus (HIV) type 1 entry inhibitor PRO 542 in HIV-infected adults. J Infect Dis 182 326-329... 

Platt EJ, Dumin IP, Rabat D (2005) Kinetic factors control efficiencies of cell entry, efficacies of entry inhibitors, and mechanisms of adaptation of human immunodeficiency virus, J Virol 79 4347 356... 

Daelemans, D., Schols, D., Witvrouw, M., Rannecouque, C., Hatse, S., Door-EN, S.V., Hamy, F., Klimkait, X, Clercq, E.D., and Vandamme, A.-M. A second target for the peptoid Xat/transactivation response element inhibitor CGP64222 Inhibition of human immunodeficiency virus replication by blocking CXC-chemo-kine receptor 4-mediated virus entry. 

Reeves JD, Miamidian JL, Biscone MJ, et al. Impact of mutations in the coreceptor binding site on human immunodeficiency virus type 1 fusion, infection, and entry inhibitor sensitivity. J Virol 2004 78(10) 5476-5485. 

Pyrrolopyridines substituted at the 2-position of dipyridodiazepinones have been prepared for study as nonnucleoside inhibitors of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase <1997JME2430>. Compound 141, synthesized from pyrrolo[2,3-, ]pyridine as a starting material, has emerged as a novel inhibitor of HIV-1. Compound 141 acts by interfering with the initial viral entry process <2003JME4236>. 

Jiang S, Lu H, Liu S et al (2004) N-substituted pyrrole derivatives as novel human immunodeficiency virus type 1 entry inhibitors that interfere with the gp41 six-helix bundle formation and block virus fusion. Antimicrob Agents Chemother 48 4349-4359... 

Hartley, O., Dorgham, K., Perez-Bercoff, D., Cerini, F., Heimann, A., Gaertner, H., Offord, R. E., Pancino, G., Debre, P., and Gorochov, G. (2003). Human immunodeficiency virus type 1 entry inhibitors selected on living cells from a library of phage chemokines. / Virol. 77, 6637-6644. 

Soler, R Poujade, C. Evers, M. Carry, J. C. Henin, Y. Bousseau, A. Huet, T. Pauwels, R. De Clercq, E. Betulinic acid derivatives a new class of specific inhibitors of human immunodeficiency virus type 1 entry. J. Med. Chem, 1996, 39 1069-1083. 

Wang T. Inhibitors of Human Immunodeficiency Virus Type 1 (HIV-1) attachment. Part x. SAR of 4-Methoxy 6-Azaindole series of HIV gpl20 entry inhibitors and discovery of BMS-626529 and its phosphonoxymethyl prodrug BMS-663068 (Manuscript in preparation)... 

Datema, R., Rabin, L., Hincenbergs, M., Moreno, M. B., Warren, S., Linquist, V., Rosenwirth, B., Seifert, J., and McCune, J. M. (1996) Antiviral efficacy in vivo of the anti-human immunodeficiency virus bicyclam SDZ SID 791 (JM 3100), an inhibitor of infectious cell entry. Antimicrobial Agents and Chemotherapy 40,750-754. 

Human iinniunodeficiency virus. 369t. 372 Humon immunodeficiency virus infection chcmokinc receptor binders for. 387 gp4I fusion activity inhibitors for. 387-388 HIV entry inhibitors for. 387 HIV protease inhibitors for. 384-387 iniegrase inhibiion for. 388 newer agents for. 382-388 reverse transcriptase inhilulors for. 372. 379-381... 

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