Human Gene Mutation Database

The Human Gene Mutation Database http //archive.uwcm.ac.uk/ uwcm/ mg/hgmdO.html... 

Data compiled from the Human Gene Mutation Database and Lander et al. ... 

Stenson PD, Ball EV, Mort M, Phillips AD, Shiel JA, Thomas NS, et al. Human gene mutation database (HGMD) 2003 update. Hum Mutat 2003 21 577-81. 

S. Abeysinghe, N. Thomas, D. N. Cooper. Human gene mutation database - a biomedical information and research resource. Hum. Mutat. 2000, 15, 45-51. 

Human Gene Mutation Database (HGMD) www.hgmd.org Mutations/SNPs in human genes... 

Gottlieb, B., Beitel, L.K., Wu, J.H. and Trifiro, M. (2004) The androgen receptor gene mutations database (ARDB) 2004 update. Human Mutation, 23, 527-533. 

Jenkins et alf" examined the formation of mutations in the p53 gene in oesophageal cell lines following treatment with deoxycholic acid for 24 h. The authors demonstrated an increased frequency of GC to AT mutations in KYSE-30 cells at neutral pH. The lARC TP53 Mutation Database compiles (http //www-p53.iarc.fr/index.html) p53 gene mutations identified in human... 

The available data indicate that creosote is an indirect mutagen and induces gene mutation in bacteria and mouse lymphoma cells. However, a substantial database exists on the genotoxic effects of the PAHs found in the creosote mixture. More in vivo assays using human tissues with coal tar creosote, coal tar, coal tar pitch, and coal tar pitch volatiles, or specific components of these mixtures, would be useful to more completely characterize the genotoxic potential of these mixtures. 

Beroud C, Soussi T. APC gene database of germline and somatic mutations in human tumors and cell lines. Nucleic Acids Res 1996 24 121-4. 

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