Human brain cancer

Moreover, double immunoliposomes were developed in order to treat intracranial human brain cancer in mice [406], The mAbs used were the rat 8D3 mAb to the mouse transferrin receptor and the mAb against the HIR. RNAi (intereference RNA) is a new antisense gene therapy, where an expression plasmid encodes for a shRNA (short hairpin RNA). The shRNA is processed in the cell to an RNA duplex. The latter mediated RNAi. Indeed, weekly i.v. RNAi gene therapy reduced tumor expression of immunoreactive EGFR and caused an 88% increase in survival time of mice with advanced intracranial brain cancer. 

Zhang, Y., Jeong, Lee, H., Boado, R. J., and Pardridge, W. M. (2002), Receptro-mediated delivery of an antisense gene to human brain cancer cells, J. Gene Med., A, 183-194. 

Micro RNAs (miRNAs) Specific miRNA and mRNA Alterations in Human Brain Cancer... 

After weekly intravenous administration to mice with intracranial human brain cancer,... 

Miescher S, Whiteside TL, de Tribolet N, von Fliedner V. In situ characterization, clonogenic potential, and antitumor cytolytic activity of T lymphocytes infiltrating human brain cancers. J Neurosurg 1988 68 438-448. 

Kaushik, N.K., et al. Effect of jet plasma on T98G human brain cancer cells. Current Applied Physics 13(1), 176-180 (2013)... 

Aliosman, F., Caughlan, J., and Gray, G.S. (1989) Diseased DNA intrastrand cross-linking and cytotoxicity induced in human brain tumor cells by 1,3-fcis(2-chlorocthyl)-1 -nitrosourea after in vitro reaction with glutathione. Cancer Res. 49, 5954. 

Saadoun, S., Papadopoulos, M. C., Davies, D. C., Bell, B. A. and Krishna, S. Increased aquaporin 1 water channel expression in human brain tumours. Br. J. Cancer 87 621-3,... 

Boron seems to have an affinity for cancerous tumors, and this property has been exploited in radiation therapy (Hamada et al. 1983 Hatanaka 1986). Boron-10 has been used in neutron capture therapy to cure malignant sarcomas implanted in the hind legs of mice, as well as spontaneous malignant melanomas in pigs (Slatkin etal. 1986). The sulfhydral borane monomer (Bi2HnSH) is used as a B-10 carrier in neutron therapy of malignant human brain tumors and seems to be most effective at 30 pg B-lO/kg tissue (Hatanaka 1986). Polyhedral boranes attached to monoclonal antibodies that are tumor specific may become useful in tumor therapy by neutron irradiation (Parry... 

Reeves, S.A., Chavez-Kappel, C., Davis, R., Rosenblum, M., and M.A. Israel, 1992, Developmental regulation of annexin II (Lipocortin 2) in human brain and expression in high grade glioma. Cancer Res. 52(24) 6871-6. 

Expression of epidermal growth factor receptors in human brain tumors. Cancer Res. 44, 753-760. 

EAG has a rather restricted distribution in healthy tissues it expresses nearly exclusively in brain, slightly in placenta and transiently in skeletal muscle (Occhiodoro et al. 1998 Pardo et al. 1999). In contrast to its restricted distribution in normal tissues, expression of EAG has been found in several human somatic cancer cell lines including HeLa cervix carcinoma, MCF-7 and SHSY-5Y neuroblastoma derived from breast tumor, melanoma IGR1, rhabdomyosarcoma, etc. (Meyer 1998, 1999 Crociani 2003). Most notably, EAG mRNA expression was found in 100% of the human cervical cancer sam-... 

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