Hoskins studies

In a brief preliminary note Heine, Cottle, and Van Mater reported comparative results showing that zirconium tetrachloride is generally superior to aluminum chloride for the Friedel-Crafts p-acetylation of toluene with acetyl chloride. However, the results were less consistent with ZrCl, than with AICI3. Gore and Hoskins studied the Friedel-Crafts reaction of benzoyl chloride with anthracene in ethylene dichloride at 0° in the presence of 14 different catalysts. The best yields of very pure 9-benzoylanthracene were with zirconium tetrachloride (97% yield after lihrs.) and with aluminum chloride (86% yield after U hrs., 99% yield after 99 hrs.). 

Compounds of the type [PeX(R2dtc)2] have been obtained by treating [Fe(R2dtc)3] complexes with concentrated hydrohalic acids. [FeCl(Et2dtc)3] has been studied by Hoskins and White (264) it has a square pyramidal structure, with the chlorine atom at the apex, and with the Fe atom situated 62 pm above the basal plane of the four sulfur atoms. A similar structure is found (265) for the monoiodo derivative [FeI(Et2dtc)2]. The chloro complex has been synthesized (266) by the following reaction. 

Schechter et al. (7) in their studies on DDT in milk found that interfering extractives are largely removed by treatment with strong sulfuric acid. Furman and Hoskins (2) found the same treatment effective when hexachlorocyclohexane was the contaminating substance, and it has been applied in later work to numerous extracts of plants and animals. The procedure now used when either DDT or hexachlorocyclohexane is suspected is as follows ... 

Grigg A, Solal-Celigny P, Hoskin P, et al. Open-label, randomized study of pegfilgrastim vs. daily filgrastim as an adjunct to chemotherapy in elderly patients with non-Hodgkirfs lymphoma. Leak. Lymphoma 2003 44 1503-1508. 

J Hoskins, P Matsushima, DL Mullen, J Tang, G Zhao, TI Meier, T Nicas, SR Jaskunas. Gene disruption studies of penicillin-binding proteins la, lb, and 2a in Streptococcus pneumoniae. J Bacteriol 181 6552-6555, 1999. 

Ma TP, Johnson JC, Hoskins GA (1997) Organization of the zona incerta in the macaque an electron microscopic study. Anat Rec 249 259-275. 

Dulaney, M.D., B. Hoskins and l.K. Ho. 1985. Studies on low dose sub-acute administration of soman, sarin, and tabun in the rat. Acta Pharmacol. Toxicol. 57 234-241. 

Brown RC, Sara EA, Hoskins JA, et al. 1991. Factors affecting the interaction of asbestos fibres with mammalian cells a study using cells in suspension. Ann Occup Hyg 35 25-34. 

Other workers determined the entire carbohydrate spectrum of human gastric juice in an attempt to evaluate the composition of gastric mucosubstances. Richmond et al. (R4) and Hoskins and Zamcheck (H50) studied a large number of individual gastric juices in our laboratory (G55) a large pool of normal gastric juices was studied for hexoses, hexosamine, fucose, sialic acid, uronic acid, and total carbohydrate content. Results obtained in normals and patients with various gastric diseases are summarized in Tables 8 and 9. 

H49. Hoskins, L. C., and Zamcheck, N., Studies on the mucous harrier Evaluation of sialic acid as a protective factor against degradation of gastric mucus by pancreatic endopeptidases. Gastroenterology 44, 456-462 (1963). 

Odum, H.T. and Hoskin, C.M., 1958. Comparative Studies on the Metabolism of Marine Waters. Public Institute of Marine Science, Texas, Vol. 5, pp. 16—46. 

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