Hormones recombinant growth hormone

Recombinant growth hormone therapy is the main pharmacologic treatment for growth hormone deficiency in both children and adults. 

Although comparative trials have not been conducted, recombinant growth hormone products appear to have similar efficacy for treating growth hormone deficiency. 

Baxter L, Bryant J, Cave CB, Milne R. Recombinant growth hormone for children and adolescents with Turner syndrome. Cochrane Database Syst Rev 2007. 

Cronin, M.J., Pioneering recombinant growth hormone manufacturing pounds produced per mile of height J Pediatr, 1997. 131(1 Pt 2) S5-7. 

Crock PA, McKenzie JD, Nicoll AM, Howard NJ, Cutfield W, Shield LK, Byrne G. Benign intracranial hypertension and recombinant growth hormone therapy in Australia and New Zealand. Acta Paediatr 1998 87(4) 381-6. 

Glucose tolerance and insulin secretion in children before and during recombinant growth hormone treatment. Horm... 

Zeisel HJ, Lutz A, von Petrykowski W Immunogenicity to mammalian cell derived recombinant growth hormone preparation during long term treatment. Hormone Res. (1992) 37 (Suppl 2) 47-55. 

Human recombinant growth hormone connective tissue, mineral, protein, carbohydrate, and lipid metabolism... 

In this form, log a is the y-intercept and b is the slope of the line. In Figure 32.3, representative linearized plots of CL and initial volume of distribution (Pi) are shown for recombinant growth hormone (GH) across four species. 

Filler G, Amend P, Kohnert KD, Devaux S, Ehrich JH. Glucose tolerance and insulin secretion in children before and during recombinant growth hormone treatment. Horm Res 1998 50(l) 32-7. 

Pharmacologic treatment of panhypopituitarism consists of glucocorticoids, thyroid-hormone preparations, sex steroids, and recombinant growth hormone, where appropriate, as lifelong replacement therapy. 

Nine different recombinant growth hormone products are... 

Despite the lack of controlled clinical trials supporting its use, many clinicians supplement PN therapy with glutamine and recombinant growth hormone in an attempt to increase intestinal absorption and facilitate transition off PN. Recombinant growth hormone is a costly product with adverse effects, but PN is more costly and also has a serious adverse-effect pro-file. Larger controlled clinical trials are needed to determine the benefit of glutamine and rhGH in this patient population. 

Richard C, Kyle U, Chevrolet JC, et al. Lack of effects of recombinant growth hormone on muscle function in patients requiring prolonged mechanical ventilation a prospective, randomized, controlled study. Crit Care Med 1996 24(3) 403M 13. 

Degerblad M, Elgindy N, Hall K, Sjoberg HE, Thoren M. Potent effect of recombinant growth hormone on bone mineral density and body composition in adults with panhypopituitarism. Acta Endocrinol (Copenh) 1992 126 387-393. 

Kohler, M., Puschel, K., Sakharov, D., et al. (2008) Detection of recombinant growth hormone in human plasma by a 2D-PAGE method. Electrophoresis, 29,4495-4502. 

Therapeutics. Therapeutic materials represent a class of polypeptides that are a low volume, high value product. The production system need not be very efficient but the quaHty of the recombinant protein has to be extremely pure (33,34). Thus high cost mammalian production systems can be tolerated. However, some of the therapeutic proteins such as insulin, human growth hormone, interleukins, interferon, and streptokinase are produced microbially. 

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