Hormone targeting

AVP plays a central role in water homeostasis of terrestrial mammals, leading to water conservation by the kidney. OT is primarily involved in milk ejection, parturition and in sexual and maternal behaviour. Both hormones are pqDtides secreted by the neurohypophysis, and both act also as neurotransmitters in the central nervous system (CNS). The major hormonal targets for AVP are the renal tubules and vascular myocytes. The hormonal targets for OT are the myoepithelial cells... 

Being a gas, NO is freely diffusible and penetrates cell membranes easily. NO is produced by and acts within the endothelium and platelets but is also a paracrine hormone targeting vascular smooth muscle cells (VSMC) and white blood cells. 

Anterior Pituitary Hormone Hypothalamic Hormone Target Organ Primary Target Organ Hormone or Mediator... 

Hypothalamic Hormone Pituitary Hormone Target Organ Target Organ Hormone... 

Hypothalamic Hormone Anterior Pituitary Hormone Target Gland Hormone Process Affected by the Target Gland Hormone... 

Endocrine Events Susceptible to Manipulation. There are a series of events which are common to the production and action of any hormone. These events include hormone synthesis, secretion and transport hormone-target cell receptor interaction target cell response and hormone degradation. Several of these events are susceptible to manipulation by external influences that might be devised into control strategies. 

Endocrine Gland Hormones Target Organ Main Actions... 

There is no doubt that subcellular compartmentation of hormones exists. Evidence for subcellular compartmentation of plant hormones is now being reported (e.g., de la Fuente and Leopold 1972, Loveys 1977, Ohlrogge et al. 1980). Water stress induces a large rise in extrachloroplastic ABA as opposed to that inside the chloroplasts (Loveys 1977, Walton 1980). Undoubtedly, more evidence for compartmentation will emerge as hormone target sites are analyzed. Compartmentation of hormones should be viewed as a possible complication in the analysis of hormones extractable or diffusible from tissues. 

Hormone Target organ Increased oxygen consumption Increased P uptake Increased blood flow or hyx>eremia Increased susceptibility to diphtheria toxin... 

Another level of metabolism peculiar to mammals that may be involved in mutagenesis concerns hormones. The biological action of hormones begins at the level of the chromosome. Steroids bind to a receptor in the cytoplasm of hormone-target cells the hormone-receptor complex diffuses into the nucleus and induces a modification in chromatin structure as indicated by increased nuclear binding of isotopically labeled actinomycin Thyroxine diffuses... 

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