Hormone independent gene activation by truncated receptors

Hormone independent gene activation by truncated receptors 

As an extension to the deletion studies decribed above several double mutations have been constructed which, upon transfection, produced receptor derivatives truncated at both ends of the polypeptide chain [82,83,90]. These are missing both the M domain and the hormone binding domain or parts thereof but are still able to bind DNA. A receptor fragment of only 150 amino acids was sufficient for constitutive transcriptional activation. This suggests that the DNA binding domain of 

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