Omeprazole hormonal

In patients with Zollinger-Ellison syndrome, omeprazole causes significant weight gain, perhaps because of shifts in hormonal balance (SEDA-17, 419 897,898). 

Reversible peripheral edema has been reported in five women taking the proton pump inhibitors omeprazole, lansoprazole, or pantoprazole for 7-15 days for peptic disorders in recommended standard doses (29). Edema disappeared within 2-3 days of withdrawal and reappeared in all five patients after re-exposure. High-dose intravenous infusions of omeprazole and pantoprazole (8 mg/hour) caused peripheral edema in three of six young female volunteers and two of six female volunteers respectively. The edema disappeared within 24 hours of stopping the infusion. Similar high doses of omeprazole did not produce edema in male volunteers. Subsequent studies performed on 10 female volunteers to elucidate the cause of the edema did not show any changes in concentrations of serum hormones or Cl esterase inhibitor. 

Isopentenyl pyrophosphate Multinucleated cells Omeprazole Parathyroid hormone Scoparic acid A Scoparic acid B Scoparic acid C Scopadulin Scopadulcic acid A Scopadulcic acid B Scopadulciol Scopadiol Standard error Median survival Time Thymidine kinase Triphosphate... 

Mineral and metal metabolism Severe hypomagnesemia impairs parath)Toid hormone (PTH) secretion and is a recognized cause of hjrpocalcemia. Proton pump inhibitors have been associated with cases of symptomatic hj ocalcaemia and hypomagnesemia [62 ] and with refractory chronic hjrpokalemia and hypocalcemia secondary to hjrpomagnesemia, which resolved after withdrawal of omeprazole [63 ]. 

Sundell GW, Nilsson G (1986) Structure and function of the dog gastric mucosa during and after a 1-year treatment with omeprazole. II. Effects on gastric acid secretion and blood levels of gastric hormones. Scand J Gastroenterol Suppl 118 82-85... 

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