Hormonal Interferon beta

Biopharmaceuticals that are industrially produced by microbial (bacterial or yeast) fermentation include insulin, human growth hormone, hepatitis B surface antigen vaccine, alpha interferon, beta interferon, gamma interferon, granulocyte colony stimulating factor, and interleukin-2. Table 30.8 lists some of the major biopharma products, some of which are produced by mammalian cell culture. 

Systemic lupus erythematosus Malignant disease hormone Acne therapy Isotretinoin Other Interferon-beta-1 a... 

Agents that may increase theophylline levels include allopurinol, beta blockers (nonselective), calcium channel blockers, cimetidine, oral contraceptives, corticosteroids, disulfiram, ephedrine, influenza virus vaccine, interferon, macrolides, mexiletine, quinolones, thiabendazole, thyroid hormones, carbamazepine, isoniazid, and loop diuretics. 

Yamazaki K, Kanaji Y, Shizume K, Yamakawa Y, Demura H, Kanaji Y, Obara T, Sato K. Reversible inhibition by interferons alpha and beta of 125I incorporation and thyroid hormone release by human thyroid follicles in vitro. J Clin Endocrinol Metab 1993 77(5) 1439-41. 

The industry is improving therapeutic ratios— the ratio of efficacy vs. side effects. It is easiest done with biologicals naturally occurring protein molecules (e.g., beta-interferon, erythropoietin [EPO]) that can start out as better drugs. We are not referring here to biological molecules such as steroids or natural hormones, but to proteins with very specific roles in human physiology and disease states. 

GTC Biotherapeutics Human antithrombin, Human serum albumin, HIV vaccine, malaria vaccine, Monoclonal antibodies, Peptides, Fusion proteins. Beta-interferon, Interferon alpha. Glutamic acid decarboj lase. Human growth hormone. Insulin, Tissue plasminogen activator 9, 40-49... 

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