Hoffmann LaRoche

Fluorinated biphenyls have been incorporated into numerous Hquid crystal stmctures as attested by patents and pubHcations from the following organizations E. Merck GmbH (257,258) Sharp (258) Hoffmann-LaRoche (259) Kanto Chemical (260) U.K. Defence Secretariat (261) Dainippon (262) Chisso (263) Sanyo Chemical (264) and the University of Hull (265). Seiko Epson has also patented fluorinated terphenyls for Hquid crystal appHcations (266). 

The amount of Hquid crystals produced each year for appHcations is several tens of tons, with the vast majority designed specifically for display appHcations. Several of the largest producers of commercial Hquid crystals are E. Merck, Hoffmann-LaRoche Inc., and Chisso. E. M. Chemicals (Hawthorne, New York) is the distributor for E. Merck in the United States and Chisso America Inc. has an office in New York. Hoffmann-LaRoche and Di Nippon Inc. have joined forces to form a new company, Rodic. 

W. Nikolowski, ia Vitamins (3) Editoaes , P. Hoffmann-LaRoche Co. Ltd., Basle, Switzerland, (1973). 

Because feed comprises over 80% of the cost of producing and fattening cattle, the maximum utilization of ever increasingly expensive rations is of upmost importance (179). Monensin under the trade name of Rumen sin (Elanco Products) was introduced in 1976 at a recommended level of 30 ppm in cattle feed. Lasalocid having the trade name Bovatec (Hoffmann-LaRoche, Inc.) was marketed some years later. 

Woodward achieved his first signal success of a lifetime devoted to the preparation of increasingly complex natural products by total synthesis by the successful preparation of quinine. Despite its elegance, this synthesis did not provide a commercially viable alternative to isolation of the drug from chincona bark. A rather short synthesis for this drug from readily available starting materials has been only recently developed by the group at Hoffmann-LaRoche. (The economics of this synthesis are,... 

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