Hoffman-Laroche

The 1995 Canadian and United States sugar alcohol (polyol) production is shown in Table 2. The market share of each is also given. Liquids comprise 48% crystalline product comprises 39% and mannitol comprises 13% of the polyol market. An estimate of total U.S. sorbitol capacity for 1995 on a 70% solution basis was 498,000 t. ADM, Decatur, lU., produced 68,200 t Ethichem, Easton, Pa., 13,600 t Lon2a, Mapleton, lU., 45,400 t Roquette America, Gurnee, lU., 68,200 t and SPI Polyols, New Castle, Del., 75,000 t (204). Hoffman-LaRoche, which produces sorbitol for captive usage in the manufacture of Vitamin C (see Vitamins), produced about 27,300 t in 1995. 

Researchers at Novartis, Senju and Hoffman-La Roche have reported structurally related bicyclic hydroxamic acids as potent PDF inhibitors [106-108]. In 2001, screening efforts at Hoffman-LaRoche identified hydrazide (28)... 

The structures of four of the synthetic carotenoids (beta-carotene, canthaxanthin, beta-apo-8 -carotenol, beta-apo-8 -carotenoic acid) are shown in Fig. 8.2. By virtue of their conjugated double bond structure, they are susceptible to oxidation but formulations with antioxidants were developed to minimize oxidation. Carotenoids are classified as oil soluble but most foods require water soluble colorants thus three approaches were used to provide water dispersible preparations. These included formulation of colloidal suspensions, emulsification of oily solutions, and dispersion in suitable colloids. The Hoffman-LaRoche firm pioneered the development of synthetic carotenoid colorants and they obviously chose candidates with better technological properties. For example, the red canthaxanthin is similar in color to lycopene but much more stable. Carotenoid colorants are appropriate for a wide variety of foods.10 Regulations differ in other countries but the only synthetic carotenoids allowed in foods in the US are beta-carotene, canthaxanthin, and beta-8-carotenol. 

Detailed reports of the degradation of this Hoffman-LaRoche compound are limited. Compared to several other IGRs, epifenonane (Ro 10-3108) was relatively stable at pH 4 in the dark (23). 

IFN-o2 has 165 amino acids and differs from the other a-IFNs by a deletion of an aspartate residue at position 44. IFN-o2a (Hoffman-LaRoche) and IFN-o2b (Schering) are the two recombinant human IFNs licensed for clinical use in oncology. They differ by a single amino-acid substitution at position 23 (lysine in IFN-cx2a and arginine in IFN-o2b). 

Prozac is a registered trademark of Eli Lilly and Company Paxil is a registered trademark of GlaxoSmithKline. Rohypnol is a registered trademark of Hoffman LaRoche Inc. Viagra is a registered trademark of Pfizer Inc. 

As indicated earlier, plant products can be useful as starting materials for the semisynthetic preparation of other drugs. An important example in this regard is the Mexican yam, which produces a steroid precursor (diosgenin) vital to the synthesis of steroidal hormones used in oral contraceptives (i.e., progesterone). The availability of diosgenin eliminates numerous expensive steps in the organic synthesis of the basic steroid molecule. It was this discovery that contributed to the development of the pharmaceutical company Syntex (now a subsidiary of Hoffman LaRoche) and the development of the first birth control pill. 

Interferon alfa-2a Hoffman-LaRoche 9/2003 Removal of Kaposi s sarcoma indication NA... 

Roferon-A Interferon alfa-2a Hoffman- LaRoche 6/1986 Hairy cell leukemia/ AIDS-related Kaposi s sarcoma/hepatitis C/chronic myelogenous leukemia E. coli... 

J.M. Bentley etal, US Patent 6,583,134 (June 24, 2003) Assignee Hoffman-LaRoche Inc and Vemnalis Research Limited Utility Treatment of Gastrointestinal Disorders... 

Before proceeding with a discussion of the effects of 3-qulnuclidlnyl benzilate, it may be worth while to look at the available information on the lethality of single doses of the benzlllc acid esters with which we are concerned. Table 1-2 is based on information supplied by Hoffman-LaRoche, Inc., the Sterllng-Wlnthrop Research Institute, and a number of investigators (36,173,176,178-189). 

Bagdon, R.E., Garner, E. 1966 One Year Chronic Toxicity Studies of Clldlnlum Bromide in Rats. Report from Department of armacology, Hoffman-LaRoche, Inc., to management. 

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