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Hoffman la Roche

No blocking group was utilized in the Schering-Hoffman-La Roche approach instead, advantage was taken of the fact that the 7a-bromo-5a-6-ketone is the thermodynamic product ... [Pg.270]

After screening efforts identified actinonin as a potent PDF inhibitor, scientists at Hoffman-La Roche evaluated replacing the P1-P2 amide bond... [Pg.129]

Researchers at Novartis, Senju and Hoffman-La Roche have reported structurally related bicyclic hydroxamic acids as potent PDF inhibitors [106-108]. In 2001, screening efforts at Hoffman-LaRoche identified hydrazide (28)... [Pg.130]

Roferon-A Interferon a-2a Hoffman-La Roche Hairy cell leukemia, AIDS-related Kaposi s sarcoma, myelogenous leukemia, hepatitis C,... [Pg.695]

Zenapax Daclizumab Hoffman-La Roche Prevention of kidney transplant rejection... [Pg.695]

Industrial synthesis of vitamin A (Hoffman-La-Roche) goes through partial hydrogenation of an enyne (equation 161)277. A number of syntheses of pheromones, where the reduction of an enyne to a diene is the key step, have been devised. A few selected examples are given in Table 29278. During the total synthesis of endiandric acids, Nico-laou employed hydrogenation of a polyenyne intermediate with a Lindlar catalyst to generate an intermediate which underwent symmetry-allowed cyclizations to result in the natural product (equation 162)279. [Pg.454]

Roferon A (rhIFN-a-2a) Hoffman-La-Roche Hairy cell leukaemia... [Pg.224]

Roferon IFN alfa-2a Stemgen (stem cell factor) Hoffman-La Roche Amgen... [Pg.147]

Pegasys, PEG IFN a-2a Hoffman-La Roche, Inc. Chronic hepatitis C in patients not previously treated with IFN-a Combination therapy with Ribavirin Combination therapy with Copegus Oct. 2002 Dec. 2002 Feb. 2005... [Pg.150]

Alfred Ross Hoffman-La Roche AG Pharmaceutical Research CH-4002 Basel Switzerland alfred.ross roche.com... [Pg.496]

Chemical Research Laboratories, Hoffman-La Roche Inc., Nutley, New Jersey. [Pg.41]

Oppenauer, R. V. Rec. Trav. Chim. 1937, 56, 137. Rupert V. Oppenauer (1910-), bom in Burgstall, Italy, studied at ETH in Zurich under Ruzicka and Reichstei, both Nobel laureates. After a string of academic appointments around Europe and a stint at Hoffman—La Roche, Oppenauer worked for the Ministry of Public Health in Buenos Aires, Argentina. [Pg.435]

Reigner B, Williams PE, Patel 1, et al. An evaluation of the integration of pharmacokinetic and pharmacodynamics principles in clinical drug development. Experience within Hoffman La Roche. Clin Pharmacokinet 1997 33 142-52. [Pg.197]

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