Histologic characterization, consistent

The pulmonary toxicity of busulfan was first reported in 1961. No clear risk factors for the development of lung toxicity have been consistently identified. The reported incidence of lung toxicity is 6% (4). The onset is typically subacute with fever and dry cough. Bleomycin is histologically characterized by NSIP or UIP. Pulmonary veno-occlusive disease and DIP have also been reported (1). Occasionally, busulfan may lead to alveolar proteinosis secondary to massive deposition of intracellular debris. This form of alveolar proteinosis is poorly responsive to whole lung lavage, and the role of steroids is not clearly estabhshed (9). 

The anatomical distribution of the dermatitis should be consistent with the exposure, correlating with the occupational gestures and activities. The clinical appearance of contact dermatitis is habitually characterized by eczematous inflammation. A wheal-and-flare reaction is the prototype of immediate contact urticaria. However, it is impossible to make a distinction based exclusively in morphological criteria. Neither allergic nor irritant OCD has definite clinical or histological features that can lead to the diagnosis, and immediate contact reactions are most consistently characterized by a broad spectrum of clinical manifestations. 

LIP is a clinicopathologic term used to describe several disorders that can be associated with dysproteinemia, autoimmunity (e.g., connective tissue diseases), or viral infections [e.g., human immunodeficiency virus (HIV)] (1). LIP is rarely an idiopathic disorder. LIP is characterized histologically by a diffuse, prominent interstitial lymphoid infiltrate (2). The infiltrate most often diffusely invades alveolar septa it consists of lymphocytes and variable numbers of plasma cells (3). Other terms are lymphoid interstitial pneumonia, lymphoid interstitial pneumonitis, diffuse hyperplasia of BALT, lymphoplasmacytic pneumonia, and plasmacytic interstitial pneumonia. 

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