Histamine from rat mast cells

Johnson AR, Hugli TE, Muller-Eberhard HJ (1975) Release of histamine from rat mast cells by the complement peptides C3a and C5a. Immunology 28 1067-1080. 

L. M. Botana, E. Arnaez, M. R. Vieytes, et al. Non-immunological release of histamine from rat mast cells elicited by antineoplastic agents. Cancer Chemother. Pharmacol. 29 495 (1992). 

It increases vascular permeability after in-tradermal injection into rats, and releases histamine from rat mast cells in vitro. Kinetensin shows sequence similarities to neurotensin and angiotensin I [M. H. Mogard et al., Biochem. Biophys. Res. Commun. 1986, 136, 983 R. E. Garraway etal.,J. Biol. Chem. 1987, 262, 5968]. 

Ellis HV, Johnson AR, Moran NC (1970) Selective release of histamine from rat mast cells by several drugs. J Pharmacol Exp Ther 175 627 English AR, Huang HT, Sobin BA (1960) 6-Aminopenicillanic add in urine after oral administration of penicillins. Proc Soc Exp Biol Med 104 405 Epp M (1959) Serological procedures for the detection of antibodies to penicillin. Science 130 1472... 

G.T. Archer, Release of Histamine from Rat Mast Cells by Blood Treated with Dextran, Nature, Lond. 184, 1151-1152 (1959). 

Chhatwal, G.S., G. Ahnert-Hilger, L. Beress, and E. Habermann Palytoxin Induces As Well As Inhibits the Release of Histamine from Rat Mast Cells. Int. Archs. Allergy appl. Immun. 68, 97 (1982). 

Figure 4.10. Dose-relationships for histamine release from rat mast cells induced by a variety of peptides [99], No calcium was added to the extracellular medium. Each point is the mean of two or more determinations A, poly(L-lysine) (molecular weight 30.000-70,000) , succinylated poly(L-lysine) (molecular weight 30,000-70f)00) V, [n-Phe7 )SP , fD-Prcr2, D-Phe7, D-Trpv]SP, u , SP/ A, eledoisin-related peptide , eledoisin O, N-terminal tetrapeptide of substance P.

Spanish needles have also been found to have anti-allergy action at the level of mast cells and other allergy mediators.4 Spanish needles contains quercetin and ethyl caffeate, both of which have previously been shown to possess in vitro anti-inflammatory or anti-allergic mediator action.23,24 Quercetin5 has also been shown to stabilize mast cells and basophils, decrease leukotriene formation, and reduce release of histamine and other mediators.24,25 Anti-inflammatory effects have been demonstrated in rats after receiving aqueous extracts of Spanish needles leaves and stems.26,27 A related species, Bidens parviflora, has been reported to inhibit histamine release from rat mast cells in vitro.6 Spanish needles have been shown to inhibit the inflammatory mediator nuclear transcription factor kappaB (NF-kappaB) and its downstream inflammatory mediators in vitro.23... 

Takei M, Endo K, Takahashi K. Mechanism of action of MY-1250, an active metabolite of repirmast, in inhibitmg histamine release from rat mast cells. Br J Pharmacol 1992 105(3) 587-90. 

Bottinger H, Reuner KH, Aktories K (1987) Inhibition of histamine release from rat mast cells by botulinum C2 toxin. In Infernatl Archiv Allergy AppI Immun. 84 ... 

T Tsuruga, Y Ebizuka, J Nakajima, YT Chun, H Noguchi, Y litaka, U Sankawa. Biologically active constituents of Magnolia salicifolia Inhibitors of induced histamin release from rat mast cells. Chem Pharm Bull 39 3265-3271, 1991. 

Foreman JC, Jordan CC, Piotrowski W (1982) Interaction of neurotensin with the substance P receptor mediating histamine release from rat mast cells and the flare in human skin, Br J Pharmacol 77 531-539... 

Figure 2. Concentration-response relationship for Ca and antigen-induced histamine release from rat mast cells (39)...

Nakamura T, Ui M (1984) Islet-activating protein, pertussis toxin, inhibits Ca " -induced and guanine nucleotide-dependent release of histamine and arachidonic acid from rat mast cells. FEBS Lett 173 414-418... 

Two secoiridoids, hydramacrosides A (109) and B (110), isolated from the leaves of Hydrangea macrophylla var. thunbergii (Saxifragaceae) showed inhibitory effect on the histamine release from rat mast cell induced by antigen-antibody reaction with inhibition of 9.1% and 21.3%, respectively, at a concentration of 10 M [135]. 

Jasani, B., Kreil, G., Mackler, B. F., and Stanworth, D. R., 1979, Further studies on the structural requirements for polypeptide-mediated histamine release from rat mast cells, Biochem. J. 181 623-632. 

Nakagawa, H., A. Kimura, M. Takei, and K. Endo Histamine Release from Rat Mast Cells Induced by an Extract from the Sea Urchin Toxopneustes pileolus. Toxicon 20, 1095 (1982). 

Fillion, G. M., Slorach, S. A., and Junas, B., 1970, The release of histamine, heparin, and granule protein from rat mast cells treated with compound 48-80 in vitro, Acta Physiol. Scand. 78 547. 

Nakagawa, H., Kimura, A., Takei, M., and Endo, K., 1982, Histamine release from rat mast cells induced by an extract from the sea urchin Toxopneustes pileolus. Toxicon. 20 1095-1097. 

Dietary copper deficiency increases the acute inflammatory response in rats and other small laboratory animals (Schuschke et al. 1994). The release of inflammatory mediators, such as histamine and serotonin, from mast cells increases the vascular permeability of postcapillary venules and results in edema. In copper-deficient rats, release of histamine from mast cells correlates positively with frequency of the acute inflammatory response. Copper-deficient rats (0.6 mg Cu/kg DW ration for 4 weeks) have more mast cells in muscle than copper-adequate controls given diets containing 6.3 mg Cu/kg DW ration however, histamine content of mast cells is not affected (Schuschke et al. 1994). An early clinical sign of copper deficiency is a reduction in the number of circulating neutrophils the mechanism for copper-deficient neutropenia (leukopenia in which... 

The sensory neuropeptides, SP, calcitonin-gene-related peptide (CGRP) and somatostatin (SOM) rapidly release histamine from rat serosal mast cells by a non-cytotoxic mechanism [3, 62],... 

Neurotensin (NT) is a tridecapeptide (Table 4.2) first isolated from brain and gut by Carraway and Leeman [75] and reported by them to induce a rapid and transient hypotension, a cutaneous vasodilatation, and a cyanosis of the extremities in the anaesthetized rat. This report, along with others [76-78] indicating that the NT-induced hypotension and increased vascular permeability could be blocked by histamine receptor antagonists such as mepy-ramine [77] or by pretreatment with compound 48/80 [76], suggested that endogenous histamine (perhaps released from tissue mast cells) was involved in producing some of the biological effects of NT [78]. 

Dynorphin, a-neoendorphin and /1-endorphin each produced a dose-dependent (10 6 M to 10 4 M) release of histamine from rat peritoneal mast cells but not from rat mucosal mast cells which were isolated following collagenase digestion [128]. When administered intradermally to the forearms of human volunteers, dynorphin, /f-endorphin, Leu-enkephalin and morphiceptin each produced a wheal and flare reaction at nM concentrations. Mast cell degranulation was confirmed by electron microscopy of biopsy samples and by its inhibition by hyroxyzine pretreatment [129]. 

Bk has been shown to stimulate histamine release from isolated peritoneal rat mast cells [30, 87] and this secretory response, like that elicited by other peptides, requires a source of metabolic energy and is prevented by depletion of cellular Ca [30, 87]. The subsequent treatment of such cellular Ca-depleted mast cells with Bk produces an inactivation or desensitization phenomenon to the subsequent addition of extracellular Ca (secretion declines as the time... 

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