High-throughput screening discovery

Development of an effective active ingredient (high throughput screening, discovery and optimization of the basic structure, clinical development)... 

Kolb, P., Berset, C., Huang, D and Caflisch, A. (2008) Structure-based tailoring of compound libraries for high-throughput screening discovery of novel EphB4 kinase inhibitors. Proteins Structure, Function, and Bioinformatics, 73, 11-18. 

H. Wennemers, Combinatorial chemistry A tool for the discovery of new catalysts. Comb Chem High Throughput Screening 4 273-285 2001. 

Catalyst Discovery and Optimization via High-throughput Screening... 

Pozzan, A. Molecular descriptors and methods for ligand based virmal high throughput screening in drug discovery. Curr. Pharm. Des. 2006, 12, 2099-2110. 

The group at Johnson and Johnson has published several reports on their efforts to find potent H3 antagonists. High-throughput screening using the recombinant human receptor identified the imidazopyridine RWJ-20085 (30) as a weak H3 receptor ligand K — 4 pM). Medicinal chemistry efforts then led to the discovery of the piperidine propyloxy compound (31) [100]. This imidazopyridine has a A) at the human H3 receptor of 2nM and... 

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