High Production Volume Testing Initiative

Two screening reproduction toxicity study protocols were prepared by the OECD for initial evaluation of existing chemicals, especially of existing high production volume chemicals but also for initial exploratory tests at an early stage of assessing the toxicological properties of new chemicals or chemicals of concern. 

Calculated from Sunset Dates of Chemicals Subject to Final TSCA Section 4 and Related 12(b) Actions, September 1,2009, available at http //www.epa.gov/oppt/chemtest/pubs/sunsettable. html. This total does not include studies performed pursuant to the voluntary initiatives such as the High Production Volume challenge, but does include HPV chemicals that were not voluntarily studied and were later the subject of test rules. See Chapter 10. Voluntary Initiatives, for a discussion of the HPV and other voluntary programs. 

High Production Volume (HPV) Chemicals Testing Initiative... 

Primary characterization of each strain is performed to get initial knowledge about the strains and to determine their suitability for further product development. The strains are characterized for both desirable and undesirable traits, e.g., growth rate in varions fermentation media as an example of a positive trait, or atypical resistance to antibiotics as an example of an undesirable trait. The primary characterization of strains in the SSC consists of several different phenotypic tests, typically performed in 96-well microtiter plates, in volumes of 100-200 jd. In order to allow fast throughpnt and high accuracy, several processes are automated, as described in Section 10.2.1. A fiiU primary characterization of a collection of strains in microtiter plate can be completed in 2 weeks. 

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