High-molecular-weight compounds, generally

As is generally known, the conformational stability of proteins depends on intramolecular interactions and on environmental factors (the surrounding solvent different low-and high-molecular weight compounds). Often, the thermostability of isolated proteins measured in vitro is unexpectedly low, suggesting that the in vitro conditions are lacking stabilizing factors present in vivo. 

Rectal absorption of drugs from aqueous or alcoholic solutions is generally much faster than from suppositories. Non-surfactant adjuvants, such as salicylates, increase rectal absorption of water-soluble drugs and also of high molecular weight compounds, such as insulin, heparin, and gastrin. 

The experimental results have shown that, in general, the yield of oily material increases with increased time of contact of reactauts with the catalyst. This fact indicates a stepwise mechanism for the synthesis of the high molecular weight compounds that are obtained. The mechanism proposed by Fischer involved the addition of carbon monoxide to methanol, which formed first, to yield acetic acid which was subsequently reduced... 

CryoPROTEcnvE Proteins. In general, soluble proteins are either weakly effective or ineffective for preventing the freeze-inactivation of thylakoids suspended in dilute salt solutions. This is not unexpected since low concentrations of high molecular weight compounds such as proteins cannot significantly reduce the freeze-concentration of cryotoxic solutes by colligative action. However, some proteins extracted from frost-... 

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