Heterocycles natural products containing

Over the years, intensive studies in medicinal chemistry with regard to the structure-activity relationships of compounds being used in clinical praxis have revealed the exceptional position of heterocycles. Moreover, a multitude of bioactive natural products contain a heteroatom. Therefore, the development of reliable and efficient... 

Many natural products contain heterocyclic motifs, which afford addihonal recognition elements for interaction with nucleotide and protein targets. Within a given molecule, heterocycles can occur as single, tandem and multiple moieties within a given molecule (Figure 7.2). 

Synthesis of marine nonterpene natural products containing heterocyclic fragments 92MI14. 

Some amines are heterocyclic compounds—cyclic compounds in which one or more of the atoms of the ring is an atom other than carbon. Heterocyclic rings are numbered so that the heteroatom has the lowest possible number. A natural product is a compound synthesized by a plant or an animal. Alkaloids are natural products containing one or more nitrogen heteroatoms and are found in the leaves, bark, roots, or seeds of plants. 

Because a number of important natural products contain densely functionalized seven-membered rings, general methods for constructing these ring systems have been actively pursued. In recent years, annulation processes, such as [4+3] annulations between dienes and allyl cations or a nucleophilic vinylcarbene, or [5+2] annulations between heterocyclic betaines and alkenes" have been shown to be particularly versatile. ... 

Another example of a well-established class of natural products containing the thiazole heterocycle is the thiopeptide antibiotics. Often referred to as thiazolyl peptides, most of these highly modified, macrocyclic peptides inhibit protein synthesis in bacteria. They display a high inhibition... 

As a lot of natural products contain fused A-heterocycles, intramolecular Mizoroki-Heck reactions have also been extensively used in total synthesis. Magallanesine (28) [48], an... 

There are also examples citing snbstructure F in the total synthesis of natural products containing 0-heterocycles, namely in a synthetic approach to (205 )-camptothecin [106] or in the synthesis of the Amaryllidaceae alkaloids ( )-tazettine and ( )-6a-epipretazettine (Scheme 6.39) [107]. 

Natural Products Containing Nitrogen Heterocycles—Some Highlights 1990-2015... 

Natural Products Containing Oxygen Heterocycles—Synthetic Advances Between 1990 and 2015... 

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