Heptyl alcohol oxidation

Pyrolytic Decomposition. The pyrolytic decomposition at 350—460°C of castor oil or the methyl ester of ricinoleic acid spHts the ricinoleate molecule at the hydroxyl group forming heptaldehyde and undecylenic acids. Heptaldehyde, used in the manufacture of synthetic flavors and fragrances (see Elavors and spices Perfumes) may also be converted to heptanoic acid by various oxidation techniques and to heptyl alcohol by catalytic hydrogenation. When heptaldehyde reacts with benzaldehyde, amyl cinnamic aldehyde is produced (see Cinnamic acid, cinnamaldehyde, and cinnamyl... 

Although the data of Layng and Youker4 were obtained in a bulb type of apparatus, they show the progressively increasing rate of oxidation of n-heptane, heptaldehyde, and heptoic add and the stability of n-heptyl alcohol to oxidation (Fig. 32). No alcohol was found in the products from n-heptane oxidation. 

HEPTYL ALCOHOL (111-70-6) Combustible liquid (flash point 170°F/77°C). Reacts violently with strong oxidizers. Reacts, possibly violently, with alkaline earth and alkali metals, strong acids, strong caustics, aliphatic amines, isocyanates, acetaldehyde, benzoyl peroxide. 

Ethyl caproate Ethyl cinnamate Ethyl, crotonate Ethylcyclohexane Ethyl decanoate N-Ethyidiethanolamine Ethylenediamine Ethylene glycol dibutyl ether Ethylene glycol isobutyl ether Ethylene oxide 2-Ethylhexyl lactate 2-Ethylhexyl-S-lactate Ethyl octanoate Ethyl oleate Ethylsulfonylethyl alcohol Ethyl toluene Fenchyl alcohol Formaldehyde Fusel oil refined Glyceryl ricinoleate Heptane Heptyl alcohol n-Hexadecane Hexamethyidisilazane Hexamethylene diisocyanate... 

Prepare a Grignard reagent from 24 -5 g. of magnesium turnings, 179 g. (157 ml.) of n-heptyl bromide (Section 111,37), and 300 ml. of di-n-butyl ether (1). Cool the solution to 0° and, with vigorous stirring, add an excess of ethylene oxide. Maintain the temperature at 0° for 1 hour after the ethylene oxide has been introduced, then allow the temperature to rise to 40° and maintain the mixture at this temperature for 1 hour. Finally heat the mixture on a water bath for 2 hours. Decompose the addition product and isolate the alcohol according to the procedure for n-hexyl alcohol (Section 111,18) the addition of benzene is unnecessary. Collect the n-nonyl alcohol at 95-100°/12 mm. The yield is 95 g. 

Catalytic conversion of l-Octanol-2-d to ketone A quantity (29.7 ml.) of l-octanol-2-d was charged (space velocity 0.2) to a 5-mm. reactor tube containing 18 ml. of 8- to 10-mesh chromium oxide catalyst maintained at 400°. The 27.7 ml. of liquid product was fractionated in a concentric-tube etjlumn. A 60.6% yield of di-n-heptyl ketone was obtained. Approximately 17% of the alcohol was recovered "unconverted. Mass spectrometric analysis of the gaseous product showed the atomic ratio of deuterium to hydrogen to be 0.106. The molal yields of deuterium, hydrogen, and carbon monoxide produced per mole of ketone were 0.216, 2.040, and 0.815 respectively. 

When 2-heptanone (950 mg kg was administered orally to rabbits, 40% of administered dose was excreted as heptyl-2-glucuronide, and traces of the unchanged ketone were also found in the urine. Compound undergoes carbonyl reduction to a secondary alcohol and co-l oxidation to a hydroxy-ketone which is further oxidized to 2,6-heptadione. 

In our initial attempts to study the effect of (DODA) Chloride, (DODA)C, sonicated vesicles on the thiolysis of p-nitrophenylacetate (NPA) by n-heptyl mercaptan (HM) we found that metal from the probe catalyzed the oxidation of the mercaptan [Cuccovia, I.M., unpublished]. In order to avoid mercaptan oxidation we developed an alcohol injection method for the preparation of (DODA)C vesicles, that were characterized by gel filtration and by the incorporation of lipid soluble probes [15]. It is not clear, today, if the aggregates prepared by ethanol injection are highly permeable closed vesicles or other types of bilayer assemblies [16]. 

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