Big Chemical Encyclopedia

Chemical substances, components, reactions, process design ...

Articles Figures Tables About

Hept-

Pyridylmethyl)methylamino)l-oxopropyl)-3-phenylbicyclo[2.2.1]hept-5-eiie (5.54)... [Pg.122]

A solution of 7-bromo-2-(fV-methylanilino)hept-2-enenitrile (145 mg, 0.52 mmol) in cyclohexane (60 ml) was placed in a quartz tube and purged with oxygen. The sample was irradiated for 8h in a Rayonet Model RPR-100 Reactor using 254 nm light. An oxygen atmosphere was maintained during... [Pg.40]

In a similar way the use of the 2-methyl-3-isothiocyanato-4-thiocyanato-hept-3-ene (252) prepared from thiocyanogen and the oxoal-kylene phosphorane (251) yields the 2-anilino-4-propyl-5-isopropyl-thiazole (253) by condensation with aniline (Scheme 128). [Pg.299]

The balance between aromatic and aUphatic reactivity is affected by the type of substituents on the ring. Furan functions as a diene in the Diels-Alder reaction. With maleic anhydride, furan readily forms 7-oxabicyclo [2.2.1]hept-5-ene-2,3-dicarboxyhc anhydride in excellent yield [5426-09-5] (4). [Pg.74]

Furan and maleic anhydride undergo the Diels-Alder reaction to form the tricycHc 1 1 adduct, 7-oxabicyclo [2.2.1]hept-5-ene-2,3-dicarboxyHc anhydride (4) in exceUent yield. Other strong dienophiles also add to furan (88). Although both endo and exo isomers are formed initially, the former rapidly isomerize to the latter in solution, even at room temperature. The existence of a charge-transfer complex in the system has been demonstrated (89,90). [Pg.81]

Maleic anhydride has been used in many Diels-Alder reactions (29), and the kinetics of its reaction with isoprene have been taken as proof of the essentially transoid stmcture of isoprene monomer (30). The Diels-Alder reaction of isoprene with chloromaleic anhydride has been analy2ed using gas chromatography (31). Reactions with other reactive hydrocarbons have been studied, eg, the reaction with cyclopentadiene yields 2-isopropenylbicyclo[2.2.1]hept-5-ene (32). Isoprene may function both as diene and dienophile in Diels-Alder reactions to form dimers. [Pg.463]

Aqueous ring-opening metathesis polymerization (ROMP) was first described in 1989 (90) and it has been appHed to maleic anhydride (91). Furan [110-00-9] reacts in a Diels-Alder reaction with maleic anhydride to give exo-7-oxabicyclo[2.2.1]hept-5-ene-2,3—dicarboxylate anhydride [6118-51 -0] (24). The condensed product is treated with a soluble mthenium(Ill) [7440-18-8] catalyst in water to give upon acidification the polymer (25). Several apphcations for this new copolymer have been suggested (91). [Pg.453]

Some important apphcations of MSC are shown in equations 2—4 (388,400). A pharmaceutical intermediate, 2-azabicyclo[2.2.1]hept-5-en-3-one is produced by equations 3 and 4. [Pg.153]

In the period up to 1970 most P-lactam research was concerned with the penicillin and cephalosporin group of antibiotics (1). Since that time, however, a wide variety of new mono- and bicychc P-lactam stmctures have been described. The carbapenems, characterized by the presence of the bicychc ting systems (1, X = CH2) originated from natural sources the penem ring (1, X = S) and its derivatives are the products of the chemical synthetic approach to new antibiotics. The chemical names are 7-oxo-(R)-l-a2abicyclo[3.2.0]hept-2-ene-2-carboxyhc acid [78854-41-8] CyH NO, and 7-oxo-(R)-4-thia-l-a2abicyclo[3.2.0]hept-2-ene-2-carboxylic a.cid [69126-94-9], C H NO S, respectively. [Pg.3]

Garbapenem P-Lactamase Inhibitors. Carbapenems are another class of natural product P-lactamase inhibitors discovered about the same time as clavulanic acid. Over forty naturally occurring carbapenems have been identified many are potent P-lactamase inhibitors. Garbapenem is the trivial name for the l-a2abicyclo[3.2.0]hept-2-ene ring system (21) shown in Table 3. The synthesis (74), biosynthesis (75), and P-lactamase inhibitory properties (13,14,66) of carbapenems have been reviewed. Carbapenems are often more potent than clavulanic acid and include type I Cephases in the spectmm of inhibition. Table 3 Hsts the available P-lactamase inhibition data. Synergy is frequendy difficult to demonstrate because the compounds are often potent antibacterials. [Pg.49]

Penem B-Lactamase Inhibitors. The synthesis and antibacterial properties of penems, the trivial name for the 4-thia-l-azabicyclo[3.2.0]hept-2-ene ring system (24), have been reviewed (107,108). Like the closely related carbapenems, many of the penems are potent antibacterials. Additionally, penems are also susceptible to degradation by renal dipeptidase, but to a lesser extent. The limited -lactamase inhibitory data available for penems are presented in Table 4. SCH-29,482 [77646-83-4] (24, R = H, R = CH(OH)CH2, R = SCH2H ), C2qH23NO S2, is reported to be an inhibitor of type I Cephases and the OXA-2 enzyme (109). Compounds [101803-54-7] and [101914-68-5] (24, R = H, R = CH2CH(OH),... [Pg.50]

Elastomers. Ethylene—propylene terpolymer (diene monomer) elastomers (EPDM) use a variety of third monomers during polymerization (see Elastomers, ethyiene-propylene-diene rubber). Ethyhdenenorbomene (ENB) is the most important of these monomers and requires dicyclopentadiene as a precursor. ENB is synthesized in a two step preparation, ie, a Diels-Alder reaction of CPD (via cracking of DCPD) with butadiene to yield 5-vinylbicyclo[2.2.1]-hept-2-ene [3048-64-4] (7) where the external double bond is then isomerized catalyticaHy toward the ring yielding 5-ethyhdenebicyclo[2.2.1]-hept-2-ene [16219-75-3] (ENB) (8) (60). [Pg.434]

Azabicyclop.2.0]heptane circular dichroism, 7, 356 nomenclature, 7, 342 7-Azabi cyclop. 1.0]heptane synthesis, 7, 85-86 3-Azabicyclo[4.1.0]heptene, 7, 544 2-Azabicyclop.2.0]hept-6-en-3-one synthesis... [Pg.519]

Hept-l-ene [592-76-7] M 98.2, b 93 /771mm, d 0.698, n 1.400. Distd from sodium, then carefully fractionally distd using an 18-in gauze-packed column. Can be purified by azeotropic distn with EtOH. Contained the 2- and 3-isomers as impurities. These can be removed by gas chromatography using a Carbowax column at 70°. [Pg.254]

B. Tropohne. In a 1-1., three-necked, round-bottomed flask equipped with a mechanical stirrer, addition funnel, and reflux condenser are placed 500 ml. of glacial acetic acid and then, cautiously, 100 g. of sodium hydroxide pellets. After the pellets have dissolved, 100 g. of 7,7-dichlorobicyclo[3.2.0]hept-2-en-6-one is added and the solution is maintained at reflux under nitrogen for 8 hours. Concentrated hydrochloric acid is then added until the mixture is about pH 1 approximately 125 ml. of acid is required. After the addition of 1 1. of benzene, the mixture is filtered and the solid sodium chloride is washed with three 100-ml. portions of benzene. The two phases of the filtrate are separated and the aqueous phase is transferred to a 1-1. continuous extractor (Note 8) which is stirred magnetically. The combined benzene phase is transferred to a 2-1. pot connected to the extractor and the aqueous phase is extracted for 13 hours. Following distillation of the benzene, the remaining orange liquid is distilled under reduced pressure... [Pg.118]

Fractions were analyzed by vapor-phase chromatography (column 0.3 X 120 cm., 20% SE-52 on Chromosorb P 60/80, 130°, helium flow rate of 60 ml./min.). Retention times of 1.9 minutes for dicyclopentadiene and 4.6 minutes for the 7,7 dichlorobicyclo[3.2.0]hept-2-en-6-one were found. [Pg.119]

The hydrolysis of 3-ethoxy-4-ethylbicyclo[4.1.0]hept-4-en-7-one propylene acetal (1) with aqueous acetic acid in tetrahydrofiiran gives an oil with the molecular formula CnH/gOi, from which the INADEQUATE contour plot 22 and DEPT spectra were obtained. What is the compound ... [Pg.92]

The monomer, norbomene (or bicyclo[2.2.l]hept-2-ene), is produced by the Diels-Alder addition of ethylene to cyclopentadiene. The monomer is polymerised by a ring-opening mechanism to give a linear polymer with a repeat unit containing both an in-chain five-membered ring and a double bond. Both cis-and trans- structures are obtainable according to the choice of catalyst used ... [Pg.306]


See other pages where Hept- is mentioned: [Pg.121]    [Pg.122]    [Pg.67]    [Pg.411]    [Pg.106]    [Pg.106]    [Pg.383]    [Pg.387]    [Pg.711]    [Pg.712]    [Pg.1023]    [Pg.1053]    [Pg.426]    [Pg.118]    [Pg.530]    [Pg.3]    [Pg.473]    [Pg.430]    [Pg.42]    [Pg.2]    [Pg.2]    [Pg.625]    [Pg.713]    [Pg.713]    [Pg.83]    [Pg.118]    [Pg.118]    [Pg.119]   
See also in sourсe #XX -- [ Pg.463 ]

See also in sourсe #XX -- [ Pg.463 ]

See also in sourсe #XX -- [ Pg.465 ]




SEARCH



2,4-Diaza-bicyclo hept

2-Azabicyclo hept-5-en-3-one

2-Methyl-2,7-diazabicyclo hept-4-enes

2.2- dihalo-4-azabicyclo hept-5-ene ester

7- Azabicyclo hepte-2,5-dienes

7-Oxabicyclo hept-5-ene

7.7- Dichlorobicyclo] 3 2 0]hept-2-en-6-one

Alkynes Hept-2-ynes

Bicyclo hept

Bicyclo hept-1 cyclobutane

Bicyclo hept-2-ene

Bicyclo hept-2-ene oxidative cleavage

Bicyclo hept-2-ene potassium permanganate

Bicyclo hept-2-enes synthesis

Bicyclo hept-2-enes thermal isomerizations

Bicyclo hept-2-enes via retro Diels-Alder reactions

Bicyclo hept-2-enes, 7- Cope rearrangement

Bicyclo hept-3-ene, 7,7-dichloro

Bicyclo hept-3-enes photoisomerization

Bicyclo hept-3-enes rearrangement

Bicyclo hept-5-en-2-one

Bicyclo hept-5-enes thermolysis

Bicyclo hept-l-ene

Bicyclo(2.2. l]hept

Bicydo hept

Height equivalent to a theoretical plate HEPT)

Hept- prefix

Hept-1-ene

Hept-2-enonate

Hept-2-enonate reaction

Hept-2-enono-l,4-lactone

Hept-2-enose

Hept-2-enose reaction

Hept-2-yne

Hept-2-ynes, metathesis

Hept-6-enoic acid

Hept-l-ene

Hept-l-ynitol

PINENE, BICYCL0 HEPT-2-ENE

Poly(2,3-bicyclo hept-2-enes

© 2024 chempedia.info