Heparin analogous

The identification of the specific sites of interaction within the heparin pentasaccharide catalyzed the synthesis of a myriad of heparin analogs (Fig. 11). Among these were a series of nonglycosaminoglycan pentasaccharide analogs containing... 

Among them, the use in the separation and purification of biochemically important macromolecules in molecular sieves (known as Sephadex ) [145], applications in the medical field (e.g., heparin analogs) [143], and due to its moisturizing properties and proven high stability, also in cosmetic formulations and for texture improvement in food applications [141, 142]. 

In analogy to sulfated multivalent glycoconjugates (Fig. 6.26), it was possible to synthesize a simple polysulfated heparin analogous structure [97]. Recently, a highly active anti-inflammatory interaction with dPGS (Fig. 6.27) was discovered that bound other inflammatory mediators in the nanomolar range of L- and P-selectins as well as in an in vivo mouse model with contact dermatitis that was as effective as the commercial glucocorticoid prednisolone [105]. 

CS, chondroitin sulfate DS, dermatan sulfate HS, heparan sulfate (an analog of heparin) ... 

N. Ramamurthy, N. Baliga, T.W. Wakefield, P.C. Andrews, V.C. Yang, and M.E. Meyerhoff, Determination of low-molecular-weight heparins and their binding to protamine and a protamine analog using polyion-sensitive membrane electrodes. Anal. Biochem. 266, 116-124 (1999). 

Edelberg (E2-E4) extensively describes the interaction of Lp(a) with tPA-mediated plasminogen activation and the influence of heparin on this mechanism. Lp(a) inhibits this mechanism analogous to the direct activation of plasminogen by tPA on fibrin(ogen) by displacing heparin from the binding sites. 

Where a device incorporates, as an integral part, a substance which, if used separately, may be considered to be a medicinal product and which is liable to act upon the body with action ancillary to that of the device (e.g. a heparin-coated catheter), the product is classed as a medical device. However, the medicinal product is to be assessed in accordance with the requirements of Directive 75/318/EEC (replaced by 2001/83/EC and updated by 2003/63/EC). A notified body undertaking conformity assessment on a medical device which incorporates a medicinal substance having ancillary action has a responsibility to consult a national medicines agency about the medicinal substance, to verify its safety, quality and usefulness by analogy with the appropriate methods specified in Directive 75/318/EEC. 

Inhibits heparin s FGF-2 mitogenic activity in vitro N-sulfa-tion affords unique structural analogs of heparin Under in vivo evaluation as inhibitors of tumor growth... 

Heparinization, as is seen from Table 12, results not only in the increase in blood clotting time, but also in an increase of the platelet adhesion the increase in both cases being more intensive the higher the content of the immobilized heparin. It should be noted that there is a complete agreement between the scientists concerning the effect of heparin on the blood clotting time the result of the contact of blood with HCP is considered analogous to that of the direct injection of soluble heparin into the bloodstream, whereas the data on platelet adhesion is quite contradictory. 

Several studies have shown that hyaluronidase is iidiibited by ft1, Fe Cu +, Ag+, Hg2+, Zn2+, Cd2+, and Pb2+ salts [26,51,58,77,78]. Substrate analogs like chondroitin sulfate tit desulfeted chondroitin sulfate B, dermatan sulfate, keratan sulfate, heparitin sulfate, and heparin were shown to be competitive inhibitors of hyaluronidase [14,54]. 

Attempts have been made to use dextran and various derivatives in many additional ways these include the use of sulfated dextran as a synthetic analog of heparin and of dextran in oil-well drilling muds. ... 

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