Hemolytic streptococci growth

CAS 4564-87-8. C42H67N016. An antibiotic isolated from products of Streptomyces halstedii when grown in suitable media by the deep-culture method. It inhibits growth of certain Gram-positive bacteria such as staphylococci, pneumococci, and hemolytic streptococci. Mp 214C. 

CAS 114-07-8. C37H67NOB. An antibiotic produced by growth of Streptomyces erythreus Waksman. It is effective against infections caused by Gram-positive bacteria, including some 3-hemolytic streptococci, pneumococci, and staphylococci. 

Recent studies of the exact nutritional requirements of various strains of hemol3 tic streptococci have resulted in their cultivation on media of completely defined chemical composition (232, 342, 449). Riboflavin has been included in the media in all cases, on the grounds of its known behavior as a growth factor for other bacteria, but it has not been shown always to be an essential component of the media. For the strains of hemolytic streptococci grown by Woolley and Hutchings (449) and by Schuman and Farrell (342), which included members of Lancefield s groups A, B, C, D, riboflavin was essential also for Streptococcus fecalis (342). Earlier work, before these media of defined composition had been worked out, had indicated the important part plaj ed by riboflavin in the nutrition of various strains of hemolytic streptococci (290,448). 

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