Hemochromatosis gene

Wilson, I.A., Bjorkman, P.J. Unusual MHC-like molecules CDl, Pc receptor, the hemochromatosis gene product, and viral homologs. Curr. Opin. Struct. Biol. 10 67-73, 1998. 

Pietrangelo A Physiology of iron transport and the hemochromatosis gene. Am J Physiol Gastroin-test Liver Physiol 282 G403-G414,2002. 

Olynyk JK, Cullen DJ, Aquilia S, Rossi E, Summerville L, Powell LW. A population-based study of the clinical expression of the hemochromatosis gene. N Engl J Med 1999 341 718-24. 

Bulaj ZJ, PhiUips JD, Ajioka RS, Frankilin MR, Griffen LM, Guinee DJ, et al. Hemochromatosis genes and other factors contributing to the pathogenesis of porphyria cutanea tarda. Blood 2000 95 1565-71. 

Burke W, Thomson E, Khoury MJ, McDonnell SM, Press N, Adams PC, et al. Hereditary hemochromatosis gene discovery and its implications for population-based screening. JAMA 1998 280 172-8. 

Feder JN, Penny DM, Irrinki A, Lee VK, Lebron JA, Watson N, et al. The hemochromatosis gene product complexes with the transferrin receptor and lowers its... 

Ja2winska EC, Lee SC, Webb SI, HaUiday JW, Powell LW. Localization of the hemochromatosis gene dose to D6S105. Am J Hum Genet 1993 53 347-52. 

Tuomainen TP, Kontula K, Nyyssonen K, Lakka TA, Heho T, Salonen JT. Increased risk of acute myocardial infarction in carriers of the hemochromatosis gene cyc282tyr mutation. Circulation 1999 100 1274-9. 

Bathum L, Christiansen L, Nybo H, Ranberg K, Gaist D, Jeune B, et al. Association of mutations in the hemochromatosis gene with shorter fife expectancy. Arch Intern Med 2001 161 2441-4. 

Kazemi-Shirazi L, Datz C, Maier-Dobersberger T, Kaserer K, Hacld F, Polli C, et al. The relation of iron status and hemochromatosis gene mutations in patients with chronic hepatitis C. Gastroenterology 1999 116 127-34. 

Pietrangelo A. Montosi G, Totaro A, Garuti C, Conte D, CassaneUi S, et al. Hereditary hemochromatosis in adults without pathogenic mutations in the hemochromatosis gene. N Engl J Med 1999 341 725-32. 

Roest M, Van Der Schouw YT, De Valk B, Marx JJM, Tempelman MJ, De Groot PG, Sixma JJ and Banga JD (1999) Heterozygosity for a hereditary hemochromatosis gene is associated with cardiovascular mortality in women. Circulation 100 1268-1273. 

Rohlfs EM, Shaheen NJ, Silverman LM. Is the hemochromatosis gene a modifier locus for cystic fibrosis Genet Test 1998 2 85. 

Genetic and biochemical evidence has also linked the biology of metals (Fe, Cu and Zn) to Alzheimer s disease. The genetic discovery that alleles in the hemochromatosis gene accelerate the onset of disease by five years [2] has certainly validated interest in the model wherein metals (iron) accelerate the course of AD. Biochemical measurements demonstrated elevated levels of copper zinc and iron in the brains of AD patients [3]. Current models have to... 

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