Discovery genetics

Darvas, F., Szabo, I., Karancsi, T., Siegel, P., Dorman, G., Laszlo, U., and Krajcsi, P., Dual uses of in silico and in vitro metabolism data in lead discovery, ComGenex MAID is a metabolism alerting system for the early phase of drug discovery, Genet. Eng. News, B22B, 32-34, 2002. 

Brown, K.D. (1992). Start-up firms take lead in apphcation of advanced technology for drug discovery. Genetic Engineering News January, 1 6. 

Glaser, V. Trends in drug discovery. Genetic Eng. News 1998, 18, 12. 

Mandal, A., Johnson, K Wu, C,F,J, and Bornemeier, D. (2007) Identifying promising compounds in drug discovery genetic algorithms and some new statistical techniques,/, Chem. Inf. Model., 47, 981-988. 

By combining facile electrical measurements with controllable physical and chemical stimuli at the micron level, microfluidic devices are developing into a versatile platform for cell-based biosensors, drug discovery, genetic analysis, and diagnostics. 

The stage was set for the fifth period of the industry by genetic engineering (qv) discoveries (5—7), ie, the in vitro manipulation of microorganisms. 

One of the greatest scientific revolutions in history is now under way in molecular biology, as scientists are learning how to manipulate and harness the genetic machinery of organisms. None of the extraordinary advances of the past two decades would have been possible, however, were it not for the discovery in L977 of methods for sequencing immense DNA chains. 

A study that investigates the statistical associations between a phenotype and a very large number of genetic markers supposed to inform on the global variability of the genome. Because GWA studies do not rely on a priori knowledge, they may lead to the discovery of new causes of disease. 

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