Stress proteins heme oxygenase

The same argument can be made for other inducible proteins which may cause tolerance. Heat shock proteins are induced in human fibroblasts by Cd(II), Cu(II), As(III), Zn(II), and Hg(II), but not by Co(U), Ni(II), Fe(II), Fe(III), Mn(II), Pt(II), or Pb(II) (Levinson et al. 1980). Like metallothionein, heat shock proteins have been postulated to play a role in the acquisition of tolerance to agents which induce its synthesis. Cd(II) and arsenite also induce heme oxygenase, a protein associated with oxidative stress (Keyse and Tyrrell 1989). 

A dipeptide Met- , derived from sardine muscle (Matsufuji et ah, 1994), stimulates expression of the antioxidant defense protein HO-1 in a concentration-dependent manner. Previous findings revealed that HO-1 protein expression is accompanied by the induction of a secondary antioxidant protein, ferritin. In a present study, the effect of Met- on the expression of the antioxidant stress proteins, heme oxygenase-1 (HO-1), and ferritin in endothelial cells derived from the human umbilical vein and their contribution to the decrease in radical formation that occurs under the influence of this dipeptide were studied and reported potential activity (Erdmann et ah, 2006). 

Murphy B.J., K.R. Laderoute, S.M. Short, and R.M. Sutherland (1991). The identification of heme oxygenase as a major hypoxic stress protein in Chinese hamster ovary cells. Br. J. Cancer 63 69-73. 

Keyse SM, Tyrrell RM. Heme oxygenase is the major 32kDa stress protein induced in human skin fibroblasts by UVA radiation, hydrogen peroxide, and sodium arsenite. Proc. Natl. Acad. Sci. U.S.A. 1989 86 99-103. 

Taketani, S., Kohno, H., Yoshinaga, T., and Tokunaga, R. (1989). The human 32-kDa stress protein induced by exposure to arsenite and cadmium ions is heme oxygenase. FEBS Lett. 245, 173-176. 

Dore, S., Takahashi, M., Ferris, C.D., Zakhary, R., Hester, L.D., GuasteUa, D. and Snyder, S.H. 1999. Bilirubin, formed by activation of heme oxygenase-2, protects neurons against oxidative stress injury. Proc. Natl. Acad. Sci. USA 96 2445-2450 Domer, A.J., Wasley, L.C. and Kaufman, R.J. 1990. Protein dissociation from GRP78 and secretion are blocked by depletion of cellular ATP levels. Proc. Natl. Acad. Sci. USA 87 7429-7432... 

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Misra S, Zararullah M, Price-Haughey J, Gedamu L (1989) Analysis of stress-induced gene expression in fish cell lines exposed to heavy metals and heat shock. Biochim Biophys Acta 1007 325-333 Mitani K, Fujita H, Sassa S, Kappas A (1990) Activation of heme oxygenase and heat shock protein 70 genes by stress in human hepatoma cells. Biochem Biophys Res Commun 166 1429-1434... 

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