Hematopoietic cell type

Blood concentrations of some hematopoietic cell types may not be reflective of total body content. 

The scope of this document does not permit a thorough discussion of hematopoiesis, pathogenesis, or normal homeostasis. It is also assumed that the reader has a basic understanding of the function of each of the hematopoietic cell types. Excellent references on these topics are available as background information (Feldman et al., 2000 Beutler et al., 2001 Greer et al., 2003 Latimer et al., 2003). 

Zhou P, Qian L, Bieszczad CK, Noelle R, Binder M, Levy NB, Craig RW Mcl-l in transgenic mice promotes survival in a spectmm of hematopoietic cell types and immortalization in the myeloid lineage. Blood 1998 92 3226-3239. 

Producing cells Hematopoietic cells, mainly leukocytes Fibroblasts and some epithelial cell types Hematopoietic cells, mainly leukocytes Immune cells, mainly T cells and NK cells Hematopoietic cells, mainly monocytes Hematopoietic cells, mainly monocytes... 

Compare the different types of HCTs, specifically (a) the types of donors (i.e., autologous and allogeneic), (b) the source of hematopoietic cells (i.e., umbilical cord, peripheral blood progenitor cells, and bone marrow), and (c) the type of preparative regimen (i.e., myeloablative and nonmyeloablative). 

The type of HCT performed depends on a number of factors, including type and status of disease, availability of a compatible donor, patient age, performance status, and organ function. In addition to bone marrow, hematopoietic cells may be obtained from the peripheral blood progenitor cells (PBPCs) and umbilical cord blood. The essential properties of the hematopoietic cells are their ability to engraft, the speed of engraftment, and the durability of engraftment.1... 

Transplant with umbilical cord blood (UCB) offers an alternative stem cell source to patients who do not have an acceptable matched related or unrelated donor. When allogeneic hematopoietic cells are obtained from UCB, the cord blood is obtained from a consenting donor in the delivery room after birth and delivery of the placenta.32 The cord blood then is processed, a sample is sent for HLA typing, and the cord blood... 

P2Y receptors are activated by adenine and uridine nucleotides. Most of the known P2Y receptors have been detected in the nervous system [21]. The majority of P2Y receptors inhibit neuronal N-type Ca2+ channels and M-type K+ channels. P2Y1 receptors are found exclusively on platelets, on their precursor megakaryocyte cells and on certain other cultured hematopoietic cells, such as K562 leukemia cells. They can be distinguished from other P2 receptors in that ADP is the most potent natural agonist and ATP is a competitive antagonist. ADP acts via a G protein to inhibit cyclic AMP accumulation, mobilize intracellular Ca2+ and stimulate granule secretion. ADP... 

Figure 3. Distribution of RVIS in different types of genes in repopulating hematopoietic cells of T and 2" cohort animals. RVIS were classified as in Table 1. Note the strong overrepresentation of RVIS into oncogenes already in the first cohort, which even further increases after serial transplantation.

The most immature cells remain in the adherent layer that is described as cobblestone areas, and are released to the growth media upon division and maturation. Major cell types in the cellular environment are macrophages, adipocytes cells and blanket cells. From the cobblestone areas hematopoietic cells are released into the growth media until the cultures begin to decline (8 weeks or later). Sign that the hematopoietic activity is declining is predominance of macrophages in the non-adherent cell population and decline of hematopoietic cell foci in the adherent layer (Dexter 1982). 

Petersdorf EW, Anasetti C, Martin PJ, Hansen JA. Tissue typing in support of unrelated hematopoietic cell transplantation. Tissue Antigens. 2003 Jan 61(l) l-ll. 

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