Harvard mouse

Abbott, A. and Klaffke, O. (1993). Europeans protest against patent for Harvard mouse. Nature 361,574. 

With respect to the specific case of the Harvard Mouse, an equivalent European patent has been allowed, but it is currently under opposition by a... 

The first monoclonals were murine (mouse) antibodies, because the early experiments involved injecting mice with an antigen, harvesting their B cells, and then fusing a harvested B cell with an immortal tumor cell line. There were immediate ahempts to make therapeutic drugs from murine monoclonal antibodies. Scientists at Harvard Medical School tried to apply murine monoclonal antibodies for heahnenf of tumors as early as 1980. But with a very few exceptions, murine antibodies failed as drugs in humans. 

Functional Genomic Atlas of the Mouse Brain by Harvard Univesity, Boston, USA (http //mahoney.chip.org/mahoney/ database.html)... 

In vivo Toxicity. The toxicity of organic compounds has been found to vary between different strains of laboratory animals. For example, mouse strain C3H is resistant to histamine, the LD50 being 1523 mg/kg in C3H/Jax mice as compared with 230 in Swiss/ICR mice that is, the animals of the former strain are 6.6 times less susceptible to the effects of histamine. Striking differences in the toxicity of thiourea, a compound used in the treatment of hyperthyroidism, are seen in different strains of the Norway rat. Harvard rats were 11 times more resistant, and wild Norway rats were 335 times more resistant than were rats of the Hopkins strain. 

In the next 5 years, David Click in Milwaukee and Susumu Ito s students at Harvard refined the procedure of layering oxyntic cells. Click demonstrated that his oriented layer was stimulated to transport chloride by histamine and carbachol and was inhibited by prostaglandin Ito s students obtained a monolayer of mouse oxyntic cells on a Millipore membrane, and they demonstrated by electron microscopy that the cells were oriented with their canaliculi continuous with the fluid on one side of the membrane. The cells transferred chloride against an electrical gradient. 

Column 6 Homologs listed for h = human, m = mouse, f = fly, and y = yeast together with BLASTp e-scores. Column 7 For Table 4 references listed ( 1-3), see http //bunn.bwh.harvard.edu/. 

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