HapMap

HAp coatings, 14 105 HapMap project, 20 839 Hapten-antibody interactions, 9 64 Haptic sensor, for skin conditions, 3 749 Harcros antifoam, commercial defoamer, 3 24 It... 

International HapMap Project http //snp.cshl.org/ Databases, linkage maps, features of sequence variation... 

Magi R, Kaplinski L, Remm M. (2006) The whole genome tagSNP selection and transferability among HapMap populations. Pac Symp Biocomput. 535-543. 

Brooks LD. (2006) Using the HapMap in drug development. Clin Adv Hematol Oncol. 4, 423-424. 

O Shaughnessy KM. (2006) HapMap, pharmacogenomics, and the goal of personalized prescribing. BrJ Clin Pharmacol. 61, 783-786. 

Andrawiss M. (2005) First phase of HapMap project already helping drug discovery. Nat Rev... 

Lin M, Aquilante C, Johnson JA, Wu R. (2005) Sequencing drug response with HapMap. 

The International HapMap Consortium. A haplotype map of the human genome. Nature 2005 437 1299-1320. 

The analysis of the predictive role of TS polymorphisms may be more complex if the 6-bp deletion/insertion (del/ins) polymorphism in the 3 UTR is added for consideration. The 6-bp deletion allele may cause mRNA instability and reduce intratumoral TS mRNA levels (32). The improved study design on the pharmacogenetic effect of TS polymorphisms should include a global evaluation of the combined VNTR, G/C, and 6-bp del/ins polymorphisms (33). The same global analysis applies to other genes, especially when the functional polymorphism is unclear. Haplotypes may be more informative than individual genotypes. Haplotype tag SNPs (htSNPs) based on the international HapMap project may represent the next wave of pharmacogenomic studies. 

The International HapMap Consortium. The International HapMap Project. Nature 2003 426(6968) 789-796. 

---