International HapMap Project

International HapMap Project http //snp.cshl.org/ Databases, linkage maps, features of sequence variation... 

The analysis of the predictive role of TS polymorphisms may be more complex if the 6-bp deletion/insertion (del/ins) polymorphism in the 3 UTR is added for consideration. The 6-bp deletion allele may cause mRNA instability and reduce intratumoral TS mRNA levels (32). The improved study design on the pharmacogenetic effect of TS polymorphisms should include a global evaluation of the combined VNTR, G/C, and 6-bp del/ins polymorphisms (33). The same global analysis applies to other genes, especially when the functional polymorphism is unclear. Haplotypes may be more informative than individual genotypes. Haplotype tag SNPs (htSNPs) based on the international HapMap project may represent the next wave of pharmacogenomic studies. 

The International HapMap Consortium. The International HapMap Project. Nature 2003 426(6968) 789-796. 

International HapMap Project. (Internet at http // www.hapmap.org/index.html.en.) The International HapMap Consortium. The International HapMap Project. Nature 2003 426 789-96. 

International HapMap Project http //hapmap.ncbi.nlm.nih.gov/ Sequence variation resources... 

International HapMap Project. URL http //www.hapmap.org/. Partnership of scientists and funding agencies from Canada, China, Japan, Nigeria, the United Kingdom, and the United States to develop a public haplotype map that will help researchers find genes associated with human disease and response to pharmaceuticals. 

International HapMap Consortium. 2004. Integrating ethics and science in the International HapMap Project. Nat Rev Genet 5 467-75. 

The international hapmap consortium. (2003) The international hapmap project. Nature 426, 349-357. Available at http //www.hapmap.org. 

International I lapMap Consratium (2003). Tlie International HapMap Project. Nature, 426 789-794. 

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