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Halothane Tricyclic antidepressants

In 190 patients taking tricyclic antidepressants that could not be discontinued before surgery, who underwent general and 61 local or regional anesthesia, there were no changes in the cardiovascular effect of halothane, induction time with pentobarbital, propanidid, or ketamine, or the duration of depolarization or recovery time (160). The general conclusion was that it is safer to continue treatment with tricyclic antidepressants than to risk potential disruption from withdrawal before surgery. [Pg.19]

The use of both halothane and pancuronium in patients taking tricyclic antidepressant has been reported as resulting in severe tachydysrhythmias. Experiments in dogs have shown that this combination can produce ventricular fibrillation and cardiac arrest (192). Enflurane also resulted in tachycardias in dogs given both imipramine and pancuronium acutely, but not when the imipramine was given chronically for 15 days beforehand. Pancuronium should not be used in patients taking tricyclic antidepressants. [Pg.22]

Clinically important, potentially hazardous interactions with albuterol, alpha-blockers, amitriptyline, amoxapine, atenolol, beta-blockers, carteolol, chlorpromazine, clomipramine, cocaine, desipramine, doxepin, ephedra, ergotamine, furazolidone, halothane, imipramine, insulin detemir, MAO inhibitors, metoprolol, nadolol, nortriptyline, oxprenolol, penbutolol, phenelzine, phenoxybenzamine, phenylephrine, pindolol, prazosin, propranolol, protriptyline, sympathomimetics, terbutaline, thioridazine, timolol, tranylcypromine, tricyclic antidepressants, trimipramine, vasopressors... [Pg.209]

Tricyclic antidepressants may increase the risk of arrhythmias and hypotension during anaesthesia. Tachyarrhythmias have been seen in patients taking imipramine who were given halothane and pancuronium. Some very limited evidence su ests that amitriptyline may increase the likelihood of enflurane-induced seizure activity. A man taking maprotiline and lithium developed a tonic-clonic seizure when given propofol. Tricyclics may cause an increase in the duration of barbiturate anaesthesia and lower doses of barbiturates may be required. [Pg.106]

The local risks of vasoconstrictors in local anaesthetic solutions, particularly when the latter are used in the fingers or other extremities, have long been recognized. In addition, it is well known that the use of adrenaline or noradrenaline for this purpose can lead to marked rises in blood pressure, especially in patients who are taking MAO inhibitors the cardiovascular effects can be dangerous in patients with existing cardiovascular disease or where there is simultaneous treatment with either a tricyclic antidepressant (SED VIII) or with those general anaesthetics which sensitize the myocardium to the effects of catecholamines (e.g. chloroform, cyclopropane, halothane). [Pg.109]


See other pages where Halothane Tricyclic antidepressants is mentioned: [Pg.633]    [Pg.106]    [Pg.107]    [Pg.123]   
See also in sourсe #XX -- [ Pg.106 ]




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