Hair shaft cortex

The hair shaft (Figure 6.1) comprises three main structures (1) the outer cuticle responsible for the main optical and frictional properties of the fiber (2) the cortex, responsible for the bulk fiber mechanical properties such as strength and flexibility and (3) the porous medulla, which is more prominent in gray hair, but otherwise may or may not be present. Cuticle thickness varies markedly between species. Though much of our understanding of hair structural biology is derived from the study of wool, this homologous... 

Appendageal structures commonly found within the skin are the hairs, hair follicles, associated sebaceous glands, apocrine and eccrine sweat glands, and arrector pili muscles. Hairs are formed by epidermal invaginations. These keratinized structures traverse the dermis and may extend into the hypodermis. The free part of the hair above the surface of the skin is the hair shaft, and the part deep within the dermis is the hair root, which forms an expanded knob-like structure called the hair bulb. This is composed of a matrix of epithelial cells in different stages of differentiation. Hair is composed of three concentric epithelial cell layers the outermost thin cuticle, a densely packed keratinized cortex, and a central medulla of cuboidal cells. The hair follicle consists of four major components (1) internal root sheath (internal root sheath cuticle, granular layer, pale epithelial layer) (2) external root sheath (several layers similar to the epidermis) (3) dermal papilla (connective tissue) and (4) hair matrix (comparable to the stratum basale of the epidermis). 

Hair is composed of approximately 65 to 95% protein, 1 to 9% lipid, and small quantities of trace elements, polysaccharides, and water. - - The majority of hair protein is often referred to as keratin, which is a general term used to describe aggregates of protein with low or high sulfur content. These proteins are synthesized in the keratogenous zone of the hair follicle as matrix cells move upward from the hair bulb to form layers of the hair shaft. The cuticle, cortex, and medulla are comprised largely of keratin, although it is structurally different in each layer. Keratin in the exocuticle contains a high concentration of cysteine, which forms disulfide bonds which link the A-layer to the exocuticle, and this makes the cuticle... 

Keratin in the cortex comprises 85% or more of the mass of the hair shaft. Cortical keratin is composed of two types of structural proteins, matrix proteins and fibrous proteins. 2-1 Matrix proteins have a high sulfur content and contain polypeptides with a molecular weight of approximately 10 to 28 kDa. Fibrous proteins are embedded in matrix proteins and are characterized by a low sulfur content. They have a molecular weight of approximately 40 to 58 kDa. Also, matrix proteins have a nonhelical structure and are readily soluble at pH 4.5 in 0.5 M KCl, whereas fibrous proteins exhibit a helical structure and are insoluble in this same solution. 

The hair shaft is composed of three layers an outermost cuticle, a cortex of densely packed keratinized cells, and an innermost medulla of loose cuboidal or flattened cells. The cuticle is formed by a single layer of flat keratinized cells in which the free edges, which overlap like shingles on a roof, are directed toward the distal end of the shaft. The cortex consists of a layer of dense, compact, keratinized cells with their long axes parallel to the hair shaft. The medulla forms the center of the hair and is loosely filled with cuboidal or flattened cells. In the root, the medulla is solid, whereas in the shaft it contains air-filled spaces. The pattern of the surface of the cuticular cells, together with the cellular arrangement of the medulla, is characteristic for each species. 

The hair of Africans is naturally curly, having a twisted structure which gives it a springlike appearance. Hair relaxers can straighten such hair by a process transforming the basic hair shaft structure. This involves hair cortex penetration. 

Several different forms of micro-organisms were found associated with the deteriorated hairs. Organisms were observed with hyphae penetrating the cortex of an exhumed hair. Linear, segmented organisms were occasionally found wrapped around the shafts of the hairs. Spores were also occasionally found attached to the hairs. 

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