Guinea pig trachea

K.A. and Raeburn, D. (1987). Demonstration of the release of an epithelium-derived inhibitory fiictor from a novel preparation of guinea-pig trachea. Eur. J. Pharmacol. 136, 247-250. 

Casaco A, Garcia M, Gonzalez R, et al. 1985b. Induction of acetylcholinesterase inhibition in the guinea pig trachea by kerosene. Respiration 48(l) 46-49. 

F]Fluoroethylation of fenoterol does not change the in vitro affinity toward S2-ARs as evaluated with isolated guinea pig trachea. In a PET study R,R) S,S)-... 

Smooth muscle relaxant activity. The essential oil was active on the guinea pig trachea and ileum, ED , 171 and 36 mg/L, respectively . 

Cox DA, Watts SW, Cohen ML. Neomycin selectively inhibits 5-hydroxy-tryptamine-induced contraction in the guinea pig trachea. J Pharmacol Exp Ther 1996 277 954-959. 

Dahlgren SE, Dalhamn T. 1972. Antiinflammatory action of phenylmetholaxadiozole (PMO). Experimental study on the guinea pig trachea. Acta Pharmacol Toxicol 31 193-202. 

Dahlgren SE, Dalen H, Dalhamn T. 1972. Ultrastructural observations on chemically induced inflammation in guinea pig trachea. Virchows Arch Abt B Zelpathol 11 211-223. 

Endothelin has many other biological actions, but among the most important of these are the effects on the airways, the gastro-intestinal tract, the kidney and the central nervous system. In addition to its effects on the pulmonary circulation, endothelin has marked effects on non-vascular airway smooth muscle. ET-1 is a potent constrictor of guinea-pig isolated trachea, upper bronchus and parenchyma [35]. ET-2 and ET-3 also contract isolated guinea-pig trachea, although ET-3 is less potent than the other two isoforms [36]. Endothelin contracts bronchial smooth muscle from a... 

A Banyu patent, which describes 203 compounds, highlights a very similar compound (example 50) (28) which is reported to show 87% inhibition at 1.1 //M of ET-1 binding in porcine aorta receptors, and activity in vitro in the guinea-pig trachea and on rat heart perfusion pressure. There is no other published information on this series of compounds. 

Berttand, C., Geppetti, P., Baker, J. et al. (1993). Role of neurogenic inflammation in antigen-induced vascular extravasation in guinea-pig trachea. J. Immunol. 150, 1479-1485. 

Shikada, K., Yamamoto, A. and Tanaka, S. (1991). Effects of phosphodiesterase inhibitors on vasoactive intestinal peptide-induced relaxation of isolated guinea-pig trachea. Eur. J. Pharmacol. 195, 389-394. 

Structure activity relationships for a series of sympathomimetic amines having a carbostyril moiety (11) have been reported.35 The most potent (11, R3=H, R4=t-butyl) is 22,400 x isoproterenol in relaxation of guinea pig trachea, and is also more fi-2 selective than 4. Order of activity Rg H>Me>Et, R4 t-butyl>i-Pr>CMe2CH20> Bz>H.35 Another analog (11, R3=Et, R4=CHMe9) (OPC 2009) is claimed to be more active and more selective... 

Figure 12.21 shows three sets of log (DR-1) values for the (S -adrenoceptor antagonist atenolol in guinea pig tracheae the data points were obtained by blocking the effects of the agonists norepinephrine, isoproterenol, and salbuta-mol. These were chosen because they have differing efficacy for (3i- versus (S2-adrenoceptors (see Figure 12.21). If a mixture of two receptors mediates responses in this tissue, then responses to the selective agonists should be differentially sensitive to the (i -adrenoceptor-selective antagonist. In the example shown in Figure 12.21, it is not immediately...

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