Guinea pig hippocampus

Anticonvulsant action of the nucleoside transport inhibitor, soluflazine, on synaptic and non-synaptic epileptogenesis in the guinea-pig hippocampus. Epilepsy Res. 2 (2), 65-71. 

Jin W, Terman G, Chavkin C. Kappa opioid receptor tolerance in the guinea pig hippocampus. J Pharmacol Exp Ther 1997 281 123-128. 

CS442 Schlicker, E., J. Timm, J. Zentner, and M. Gothert. Cannabinoid CBl receptor-mediated inhibition of noradrenaline release in the human and guinea-pig hippocampus. Naunyn Schmiedebergs Arch Pharmacol 1997 356(5) 583-589. 

Wu LG, Saggau P (1994) Adenosine inhibits evoked synaptic transmission primarily by reducing presynaptic calcium influx in area CA1 of hippocampus. Neuron 12 1139—48 Wu LG, Saggau P (1995) GABAB receptor-mediated presynaptic inhibition in guinea-pig hippocampus is caused by reduction of presynaptic Ca2+ influx. J Physiol 485 649-57 Wu LG, Saggau P (1997) Presynaptic inhibition of elicited neurotransmitter release. Trends Neurosci 20 204—12... 

Caudle, R. M., and Dubner, R. (1998). Ifenprodil blocks the excitatory effects of the opioid peptide dynorphin 1-17 on NMDA receptor-mediated currents in the CA3 region of the guinea pig hippocampus. Neuropeptides 32, 87-95. 

Frotscher M (1985) Mossy fibres foim synapses widi idendfied pyramidal basket cells in die CA3 region of die guinea-pig hippocampus A combined Golgi-elecfion microscope study. J Neurocytol 14 245-259. 

Altschuler RA, Monaghan DT, Haser WG, Wenthold RJ, Curthoys NP, Cotman CW (1985) Immunocytochemical localization of glutaminase-like and aspartate aminotransferase-like immunoreactivities in the rat and guinea pig hippocampus. Brain Res 330 225-233. 

Noradrenaline Guinea-pig Hippocampus P HJNoradrenaline release Inverse agonists (SR 141716, AM 251, AM Schlicker et al. 1997,2002... 

Acetylcholine Guinea-pig Hippocampus H]Acetylcholine release Inverse agonist (SR 141716) SchultheiG etal. 2004... 

SchultheiK T, Flau K, Redmer A, Kathmann M, Reggio PH, Seltzman HH, Schlicker E (2004) The facilitatory effect of SR 141716 on transmitter release in guinea-pig hippocampus is due to its inverse agonist activity at cannabinoid CB i receptors. Naunyn-Schmiedeberg s Arch Pharmacol 369 (Suppl 1 ) R84... 

Table 2.2. EQUILIBRIUM DISSOCIATION CONSTANTS OF HrRECEPTOR ANTAGONISTS ON PERIPHERAL AND CENTRAL H2-RECEPTORS Values represent measurements made on guinea-pig atria [42,43,78,80], homogenates of guinea-pig hippocampus (adenylate cyclase) [81], slices of rabbit cerebral cortex (cyclic AMP accumulation) [82] and homogenates of guinea-pig cerebral cortex ([3H]tiotidine binding) [83].

The H2-stimulated adenylate cyclase response is sensitive to inhibition by a range of psychotropic drugs. A large number of neuroleptic drugs are effective inhibitors of histamine-stimulated cyclase activity in rabbit cerebral cortex [158, 192] and guinea-pig hippocampus and cerebral cortex [81, 193]. The most potent compounds in homogenates of guinea-pig hippocampus appear to... 

Table 2.6. COMPARISON OF THE POTENCY OF INHIBITORS OF H2-RECEPTOR-MEDIATED CYCLIC AMP ACCUMULATION IN BRAIN SLICES, DISSOCIATED CELLS AND HOMOGENATES OF GUINEA-PIG HIPPOCAMPUS Values represent measurements made on H2-mediated adenylate cyclase activity in homogenates of guinea-pig hippocampus [182,183,193], on impromidine-stimulated cyclic AMP accumulation in hippocampal slices [195] and on H2-mediated cyclic AMP accumulation in dissociated...

Studies of histamine-stimulated adenylate cyclase activity in broken cell preparations of both peripheral and central tissues suggest that the effect of histamine on cyclic-AMP-generating systems is exclusively associated with H2-receptor stimulation [83, 179-183, 188-191]. The data obtained with selective H2-receptor antagonists in slices of guinea-pig hippocampus [ 165]... 

In a recent study, Turner and Schwartzkroin (1980) attempted to estimate the voltage and current transfer between the soma and dendrites of CAl pyramidal cells of the guinea pig hippocampus, by recording from the cells intracellularly and then injecting HRP to visualize the detailed anatomy of the dendritic tree. All of the cells were oriented within the transverse plane of the slice and almost completely contained within one 75-pm section cut parallel to the surface of the slice. Although a few processes were found in adjacent sections, the major part of the tree was extremely flat and only 25-50 pm thick. 

Jeffrys, J. G. R., 1979, Initiation and spread of action potentials in granule cells maintained in vitro in slices of guinea-pig hippocampus,/. Physiol. London) 289 375. 

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