Guillain-Barre syndrome inflammatory demyelinating

Guillain-Barre syndrome is a transient neurologic disorder involving inflammatory demyelination of the peripheral nerves. The syndrome is characterized by progressive symmetric weakness of the legs and arms with loss of reflexes. Occasionally sensory abnormalities and paralysis of respiratory muscles will occur.16... 

Acute inflammatoiy demyelinating polyneuropathy is a common cause of reversible paralysis. Acute inflammatory demyelinating polyneuropathy (AIDP), the classic form of the Guillain-Barre syndrome, often begins a week or two after recovery from cytomegalovirus, Epstein-Barr virus or Mycoplasma infection. Patients present with rapidly advancing symmetrical weakness, loss of deep tendon reflexes, often with distal numbness, and limb or back pain. Cerebrospinal fluid (CSF) protein concentration is elevated, but in most cases there is little or no increase in number of inflammatory cells in the CSF. This albumino-cytologic dissociation contrasts with the elevation of both... 

Magira, E. E., Papaioakim, M., Nachamkin, I. et al. Differential distribution of HLA-DQP/DRP epitopes in the two forms of Guillain-Barre syndrome, acute motor axonal neuropathy and acute inflammatory demyelinating... 

Guillain-Barre Syndrome, Chronic Inflammatory Demyelinating Polyradiculoneuropathy, and Axonal Degeneration and Regeneration... 

Takigawa T, Yasuda H, Terada M, Haneda M, Kashiwagi A Saito T, Saida T, Kitasato H, Kikkawa R (2000) The sera from GMl gan-glioside antibody positive patients with Guillain-Barre syndrome or chronic inflammatory demyelinating polyneuropathy blocks Na+ currents in rat single myehnated nerve fibers. Intern Med 39 123-127. 

Isolated reports of adverse effects have included abscess formation (SEDA-11, 288) dermatomyositis, neuralgic amyotrophy, polyradiculoneuritis with paresis of the urinary bladder and bowel (SEDA-9, 283) asymmetrical polyneuropathy, demyelinating polyneuropathy, and Guillain-Barre syndrome (SEDA-14, 281) and subcutaneous nodules. Polyvinylpyrrolidone thesaurismosis, revealed by inflammatory manifestations after tetanus booster injection, has also been reported (SEDA-10,288). 

FIGURE 20.61 Locations of T lymphocytes among sural nerve biopsy specimens from 13 cases of chronic inflammatory demyelinat-ing polyneuropathy (CIDP) and 22 cases of Guillain-Barre syndrome (CBS). Percentages positive are as reported in Schmidt B, Toyka KV, Keifer R, et al. Inflammatory infiltrates in sural nerve biopsies in Guillain-Barre syndrome and chronic inflammatory demyelinating neuropathy. Muscle Nerve. 1996 19 474-487. 

Schmidt B, Toyka KV, Kiefer R, et al. Inflammatory infiltrates in strral nerve biopsies in Guillain-Barre syndrome and chronic inflammatory demyelinating neuropathy. Muscle Nerve. 1996 19 474-487. 

Peripheral neuropathies, autoimmune. Acute or chronic inflammatory neuropathies leading to demyelination and axonal damage of nerves and nerve roots associated with high-titred autoantibodies against gangliosides (e.g. Guillain-Barre syndrome, Miller-Fisher syndrome, acute sensory ataxic neuropathy). 

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