Chronic inflammatory demyelinating polyneuropathy

PARK p-adrenergic receptor kinase CIDP chronic inflammatory demyelinating polyneuropathy... 

Chronic inflammatory demyelinating polyneuropathy is sometimes associated with malignancy [123]. The reported incidence of carcinoma in chronic inflammatory demyelinating polyneuropathy varies from 4 to 10% [100, 124]. 

Elderly patients with chronic inflammatory demyelinating polyneuropathy and a subacute onset and poor response to treatment are particularly prone to harboring an underlying malignancy [125],... 

Antoine JC, Mosnier JF, Lapras J, Convers P, Absi L, Laurent B, et al. Chronic inflammatory demyelinating polyneuropathy associated with carcinoma. J Neurol Neurosurg Psychiatry 1996 60(2) 188-190. 

Hies Z, Kondo T, Newcombe J, Oka N, Tabita T, Yamamura T (2000) Differential expression of NK T cell V alpha 24J alpha Q invariant TCR chain in the lesions of multiple sclerosis and chronic inflammatory demyelinating polyneuropathy. J Immun 164 4375 381. 

Yamamoto M, Ito Y, Mitsuma N, Li M, Hattori N, Sobue G (2002) Parallel expression of neurotrophic factors and their receptors in chronic inflammatory demyelinating polyneuropathy. Muscle Nerve 25 601-604. 

Takigawa T, Yasuda H, Terada M, Haneda M, Kashiwagi A Saito T, Saida T, Kitasato H, Kikkawa R (2000) The sera from GMl gan-glioside antibody positive patients with Guillain-Barre syndrome or chronic inflammatory demyelinating polyneuropathy blocks Na+ currents in rat single myehnated nerve fibers. Intern Med 39 123-127. 

Various forms of interferon alfa-induced neuropathy have been reported (SED-14,1249), but chronic inflammatory demyelinating polyneuropathy has seldom been described (61,62). 

A chronic inflammatory demyelinating polyneuropathy was considered to have been caused by tacrolimus in a 62-year-old patient (30). 

Matsrrmuro K, Izumo S, Umehara F, et al. Chronic inflammatory demyelinating polyneuropathy Histological and immu-nopathological studies on biopsied sural nerves. J Neurol Sci. 1994 127 170-178. 

In a patient who does have a close family history of diabetes-2, a glucocorticoid should be avoided if possible, because it can increase insulin resistance and make manifest diabetes-2 glucose dysmetabo-lism. Accordingly, asking about a close family history of diabetes-2 is very important in managing a chronic immune dysschwannian polyneuropathy (CIDP) (sometimes less precisely called chronic inflammatory demyelinating polyneuropathy), or other dysimmune patient. 

Treatment Because of the sensory abnormalities, dysschwannian nerve conductions, elevated CSF protein, aspects of denervation-reinnervation in the muscle biopsy, and the diabetes-2 in both parents, we considered that our patient probably had coexisting genetico-diahetoid-2 dysimmune neuropathy," a type of chronic immune dysschwannian polyneuropathy (CIDP) (sometimes less precisely called chronic inflammatory demyelinating polyneuropathy, Chapter 2). We therefore treated her using/WG, and she was remarkably benefited her walking ability and endurance greatly improved, she did not require frequent rests, and was able to ascend steps much more easily. 

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